N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-1,3-benzodioxole-5-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[(4-methoxyphenyl)sulfamoyl]phenyl]-1,3-benzodioxole-5-carboxamide
• 化学式: C₂₁H₁₈N₂O₆S
• 分子量: 426.4
• InChiKey: WPSVPQJPAZKXKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF CANCER DISEASES COMPRISING BENZAMIDE DERIVATIVES<br/>[FR] COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION ET LE TRAITEMENT DE MALADIES CANCÉREUSES, COMPRENANT DES DÉRIVÉS DE BENZAMIDE
  申请人：SK HOLDINGS CO LTD

  公开号：WO2010150927A1

  公开（公告）日：2010-12-29

  There is provided a pharmaceutical composition for prevention and treatment of cancer diseases comprising benzamide derivatives. The pharmaceutical composition comprises benzamide derivatives represented by the following formula 1 as indicated in the specification, or pharmaceutically available salts thereof. Therefore, the pharmaceutical composition may be useful to prevent or treat a variety of cancer diseases such as colorectal cancer (CRC) since the pharmaceutical composition is associated with the cell growth inhibition and the tumor growth retardation, including the suppression of the Wnt signaling pathway.