N-(5-chloro-2-hydroxyphenyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-chloro-2-hydroxyphenyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide
• 化学式: C₂₅H₁₇ClN₄O₂
• 分子量: 440.9
• InChiKey: KSCQJOIIEBQEJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS WITH ANTIMALARIAL ACTIVITY<br/>[FR] COMPOSÉS AYANT UNE ACTIVITÉ ANTIPALUDÉENNE
  申请人：UNIV PUERTO RICO

  公开号：WO2020209932A1

  公开（公告）日：2020-10-15

  Methods of inhibiting growth of a Plasmodium species, treating malaria, and inhibiting a glutathione S-transferase are provided. The methods include inhibiting growth of a Plasmodium species comprising contacting a Plasmodium species with a compound as disclosed herein. The methods also include treating malaria comprising administering a compound as disclosed herein to a human or animal patient, preferably a human patient, in need thereof. The methods further include inhibiting a glutathione S-transferase (GST) comprising contacting a GST with a compound as disclosed herein. Also provided are compounds for use in the disclosed methods.