2-Imino-1,5-dimethyl-3,3-diphenyl-pyrrolidin | 412282-67-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Imino-1,5-dimethyl-3,3-diphenyl-pyrrolidin
• 英文别名: 1,5-dimethyl-3,3-diphenyl-pyrrolidin-2-ylideneamine；(+/-)-1,5-dimethyl-3,3-diphenyl-pyrrolidin-2-one-imine；(+/-)-1,5-Dimethyl-3,3-diphenyl-pyrrolidin-2-on-imin；2-Imino-1,5-dimethyl-3,3-diphenylpyrrolidine；1,5-dimethyl-3,3-diphenylpyrrolidin-2-imine
• CAS: 412282-67-8
• 化学式: C₁₈H₂₀N₂
• 分子量: 264.37
• InChiKey: VATHZBBIDFXIKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  27.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-(benzyl-methyl-amino)-2,2-diphenyl-valeronitrile 在 盐酸 作用下， 生成 2-Imino-1,5-dimethyl-3,3-diphenyl-pyrrolidin
  参考文献：
  名称：

  Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes

  摘要：

  Background: To evaluate the ocular toxicity of trypan blue (TB) injected into the vitreous cavity of rabbit eyes. TB is a dye that could be useful for staining epiretinal membranes during vitrectomy surgery. Methods: Ten New Zealand White (NZW) rabbits underwent gas-compression vitrectomy. Rabbits were divided into three groups to receive injections of 0.1 ml basic salt solution, 0.1 ml of a 0.06% TB solution or 0.1 ml of a 0.2% TB solution. Ocular toxicity was assessed by slit-lamp biomicroscopy, ophthalmoscopy, electroretinography and histology. Results: Transient posterior capsule opacification was noted in all animals. No significant reductions in a-wave or b-wave amplitudes were found in any of the animals. Light and electron microscopic examination of the inferior retina in the 0.2% TB-treated eyes showed damaged photoreceptors and marked disorganization. Immunohistochemical staining for rhodopsin was strongly reduced in those sections and staining for proliferation with Ki-67 was positive. No histological abnormalities were found in the upper retina of the 0.2% TB-treated eyes or in any part of the retina of the 0.06% TB-treated or control eyes. No histological abnormalities were found in any of the anterior chamber angle specimens. Conclusions: Although no signs of toxicity were found after the prolonged presence of TB at a concentration of 0.06% in the vitreous cavity of rabbit eyes, marked damage occurred in the lower retina of 0.2% TB-treated eyes. The shortterm presence of TB at a concentration of 0.06% in the vitreous cavity is harmless to the rabbit eye but a higher concentration of TB could be unsafe.

  DOI：

  10.1007/s004170100341

文献信息

• 675. Some reactions of 3-dimethylamino-1 : 1-diphenylbutyl cyanide
  作者：J. Cymerman、W. S. Gilbert

  DOI：10.1039/jr9520003529

  日期：——
• Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes
  作者：Marc Veckeneer、Koen Overdam、Jan Monzer、Karin Kobuch、Wilfried Marle、Henk Spekreijse、Jan Meurs

  DOI：10.1007/s004170100341

  日期：2001.9

  Background: To evaluate the ocular toxicity of trypan blue (TB) injected into the vitreous cavity of rabbit eyes. TB is a dye that could be useful for staining epiretinal membranes during vitrectomy surgery. Methods: Ten New Zealand White (NZW) rabbits underwent gas-compression vitrectomy. Rabbits were divided into three groups to receive injections of 0.1 ml basic salt solution, 0.1 ml of a 0.06% TB solution or 0.1 ml of a 0.2% TB solution. Ocular toxicity was assessed by slit-lamp biomicroscopy, ophthalmoscopy, electroretinography and histology. Results: Transient posterior capsule opacification was noted in all animals. No significant reductions in a-wave or b-wave amplitudes were found in any of the animals. Light and electron microscopic examination of the inferior retina in the 0.2% TB-treated eyes showed damaged photoreceptors and marked disorganization. Immunohistochemical staining for rhodopsin was strongly reduced in those sections and staining for proliferation with Ki-67 was positive. No histological abnormalities were found in the upper retina of the 0.2% TB-treated eyes or in any part of the retina of the 0.06% TB-treated or control eyes. No histological abnormalities were found in any of the anterior chamber angle specimens. Conclusions: Although no signs of toxicity were found after the prolonged presence of TB at a concentration of 0.06% in the vitreous cavity of rabbit eyes, marked damage occurred in the lower retina of 0.2% TB-treated eyes. The shortterm presence of TB at a concentration of 0.06% in the vitreous cavity is harmless to the rabbit eye but a higher concentration of TB could be unsafe.