2-[(4-Chloro-3-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-Chloro-3-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
• 化学式: C16H14ClN3O4S
• 分子量: 379.8
• InChiKey: BPFCBZAPZQLDQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Assay for compounds that protect against sensory hair cell death and compounds identified by same
  申请人：Ou C. Henry

  公开号：US20060188445A1

  公开（公告）日：2006-08-24

  The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.

  本发明提供了鉴定可防止由一种或多种有害刺激诱发的耳毒性的化合物的方法，以及用本筛选方法鉴定的化合物治疗个体的方法。本发明还提供了经证实具有耳保护作用的化合物。
• OTIC FORMULATIONS FOR DRUG-INDUCED OTOTOXICITY
  申请人：Otonomy, Inc.

  公开号：EP3810146A1

  公开（公告）日：2021-04-28
• COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH
  申请人：Ou Henry C.

  公开号：US20090023751A1

  公开（公告）日：2009-01-22

  The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.
• US8232314B2
  申请人：——

  公开号：US8232314B2

  公开（公告）日：2012-07-31