2-(2-acetamidophenyl)-N-(2,5-dimethoxyphenyl)-2-oxoacetamide | 656813-29-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-acetamidophenyl)-N-(2,5-dimethoxyphenyl)-2-oxoacetamide
• CAS: 656813-29-5
• 化学式: C₁₈H₁₈N₂O₅
• 分子量: 342.351
• InChiKey: LTKDHWZZHFCPPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-乙酰基靛红 、 2,5-二甲氧基苯胺 反应 18.0h， 以40%的产率得到2-(2-acetamidophenyl)-N-(2,5-dimethoxyphenyl)-2-oxoacetamide
  参考文献：
  名称：

  New isatin derivatives with antioxidant activity

  摘要：

  The reaction between isatin and 2,5-dimethoxyaniline is described. The main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one. The antioxidant activity of the compounds isolated was evaluated with two methods. Three published antitumor E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones entered the same tests to search whether they are endowed with antioxidant activity too. 3,3-Bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one and the three antitumor agents showed a good chemical antioxidant activity. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.035

文献信息

• New isatin derivatives with antioxidant activity
  作者：Aldo Andreani、Silvia Burnelli、Massimiliano Granaiola、Alberto Leoni、Alessandra Locatelli、Rita Morigi、Mirella Rambaldi、Lucilla Varoli、Mauro Andrea Cremonini、Giuseppe Placucci

  DOI：10.1016/j.ejmech.2009.12.035

  日期：2010.4

  The reaction between isatin and 2,5-dimethoxyaniline is described. The main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one. The antioxidant activity of the compounds isolated was evaluated with two methods. Three published antitumor E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones entered the same tests to search whether they are endowed with antioxidant activity too. 3,3-Bis(4-amino-2,5-dimethoxyphenyl)-1,3-dihydroindol-2-one and the three antitumor agents showed a good chemical antioxidant activity. (C) 2009 Elsevier Masson SAS. All rights reserved.