N-[2-(1H-benzimidazol-2-yl)ethyl]-3,4-dichlorobenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(1H-benzimidazol-2-yl)ethyl]-3,4-dichlorobenzenesulfonamide
• 化学式: C₁₅H₁₃Cl₂N₃O₂S
• 分子量: 370.3
• InChiKey: UTWRWPNZFSXENL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  83.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• BENZIMIDAZOLES USEFUL AS MODULATORS OF ION CHANNELS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1678145A2

  公开（公告）日：2006-07-12
• Benzimidazoles useful as modulators of ion channels
  申请人：Wilson M. Dean

  公开号：US20050209282A1

  公开（公告）日：2005-09-22

  The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R 1 , Z, Y, R A , and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
• US7309716B2
  申请人：——

  公开号：US7309716B2

  公开（公告）日：2007-12-18
• US7705031B2
  申请人：——

  公开号：US7705031B2

  公开（公告）日：2010-04-27
• [EN] BENZIMIDAZOLES USEFUL AS MODULATORS OF ION CHANNELS<br/>[FR] BENZIMIDAZOLES CONVENANT COMME MODULATEURS DES CANAUX IONIQUES
  申请人：VERTEX PHARMA

  公开号：WO2005042497A2

  公开（公告）日：2005-05-12

  The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of suing the compositions in the treatment of various disorders.