rhaponticin | 1403836-09-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: rhaponticin
• 英文别名: (2R,3S,4S,5R,6S)-2-(aminomethyl)-6-[3-hydroxy-5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]phenoxy]oxane-3,4,5-triol
• CAS: 1403836-09-8
• 化学式: C₂₁H₂₅NO₈
• 分子量: 419.431
• InChiKey: AYEDECSNAPXAEL-DXKBKAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  155
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  勒胖停 在 Methyltriphenoxyphosphonium iodide 、 ammonium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 rhaponticin
  参考文献：
  名称：

  Regioselective synthesis and initial evaluation of a folate receptor targeted rhaponticin prodrug

  摘要：

  To improve the therapeutic effect of rhaponticin (RHA), a folate receptor (FR) targeted RHA prodrug was designed and regioselectively synthesized by utilizing a hydrophilic peptide spacer linked to folic acid (FA) via a releasable disulfide linker. A series of biological evaluation was investigated in vitro and in vivo. The positive results of biological investigations warrant further preclinical study before this novel targeted chemotherapeutic is considered for clinical investigation. (C) 2012 Jun Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.08.006

文献信息

• Regioselective synthesis and initial evaluation of a folate receptor targeted rhaponticin prodrug
  作者：Xu Hua Liang、Yang Sun、Lu Sha Liu、Ying Yong Zhao、Xiao Yun Hu、Jun Fan

  DOI：10.1016/j.cclet.2012.08.006

  日期：2012.10

  To improve the therapeutic effect of rhaponticin (RHA), a folate receptor (FR) targeted RHA prodrug was designed and regioselectively synthesized by utilizing a hydrophilic peptide spacer linked to folic acid (FA) via a releasable disulfide linker. A series of biological evaluation was investigated in vitro and in vivo. The positive results of biological investigations warrant further preclinical study before this novel targeted chemotherapeutic is considered for clinical investigation. (C) 2012 Jun Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.