3-methoxy-N-[4-(1-pyrrolidinyl)phenyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methoxy-N-[4-(1-pyrrolidinyl)phenyl]benzamide
• 英文别名: 3-methoxy-N-(4-pyrrolidin-1-ylphenyl)benzamide
• 化学式: C₁₈H₂₀N₂O₂
• 分子量: 296.4
• InChiKey: ZZJGTLJERDOEQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Anti-neoplastic compounds and methods targeting QSOX1
  申请人：ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

  公开号：US10894034B2

  公开（公告）日：2021-01-19

  Compounds and methods involving inhibition of the enzymatic activity of QSOX1 (FIG. 13). The compounds and methods can be used in treatment of neoplastic cells, for example, to suppress tumor growth and invasion in a variety of cancers, including but not limited to myeloma and cancers of the breast, kidney, and pancreas.

  涉及抑制 QSOX1 酶活性的化合物和方法（图 13）。这些化合物和方法可用于治疗肿瘤细胞，例如抑制各种癌症中的肿瘤生长和侵袭，包括但不限于骨髓瘤以及乳腺癌、肾癌和胰腺癌。
• ANTI-NEOPLASTIC COMPOUNDS AND METHODS TARGETING QSOX1
  申请人：ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

  公开号：US20190008829A1

  公开（公告）日：2019-01-10

  Compounds and methods involving inhibition of the enzymatic activity of QSOX1 (FIG. 13 ). The compounds and methods can be used in treatment of neoplastic cells, for example, to suppress tumor growth and invasion in a variety of cancers, including but not limited to myeloma and cancers of the breast, kidney, and pancreas.
• [EN] ANTI-NEOPLASTIC COMPOUNDS AND METHODS TARGETING QSOX1<br/>[FR] COMPOSÉS ANTI-NÉOPLASIQUES ET PROCÉDÉS CIBLANT QSOX1
  申请人：UNIV ARIZONA STATE

  公开号：WO2017048712A1

  公开（公告）日：2017-03-23

  Compounds and methods involving inhibition of the enzymatic activity of QSOX1 (Fig. 13). The compounds and methods can be used in treatment of neoplastic cells, for example, to suppress tumor growth and invasion in a variety of cancers, including but not limited to myeloma and cancers of the breast, kidney, and pancreas.
• [EN] COMPOUNDS AND METHODS TARGETING QSOX1<br/>[FR] COMPOSÉS ET PROCÉDÉS CIBLANT QSOX1
  申请人：SAPPHIRE BIOTECH INC

  公开号：WO2021077031A1

  公开（公告）日：2021-04-22

  Provided herein are compounds and methods for targeting QSOX1 and ameliorating QSOX1-mediated diseases.