Cambridge id 6808916

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Cambridge id 6808916
• 英文别名: (4-tert-butylphenyl)-(4-ethylpiperazin-1-yl)methanone
• 化学式: C₁₇H₂₆N₂O
• 分子量: 274.4
• InChiKey: BOWMYSFEPWXLKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• TRIAZOLOPYRIDINE DERIVATIVES AS A TYROSINE KINASE INHIBITOR
  申请人：HANMI PHARM. CO., LTD.

  公开号：US20140364438A1

  公开（公告）日：2014-12-11

  Provided is a novel triazolopyridine derivative having irreversible tyrosine kinase inhibiting activities, and a pharmaceutical composition comprising the same which can be useful for prevention or treatment of inflammatory diseases, autoimmune diseases, proliferative diseases or hyperproliferative diseases, immunologically mediated diseases, cancers or tumors.

  提供了一种新型三唑并吡啶衍生物，具有不可逆的酪氨酸激酶抑制活性，以及包含该衍生物的药物组合物，可用于预防或治疗炎症性疾病、自身免疫性疾病、增殖性疾病或过度增殖性疾病、免疫介导性疾病、癌症或肿瘤。
• MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
  申请人：PARK John Edward

  公开号：US20100204211A1

  公开（公告）日：2010-08-12

  The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R 1 to R 5 and X are defined as in claim 1 , the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.

  本发明涉及使用通式中6位取代的吲哚酮，其中R1至R5和X如权利要求1所定义，其异构体和盐，特别是其生理上可接受的盐，作为预防或治疗特定纤维化疾病的药物。
• INDAZOLYL TRIAZOL DERIVATIVES
  申请人：Jorand-Lebrun Catherine

  公开号：US20130274241A1

  公开（公告）日：2013-10-17

  Compounds of Formula (I) are used for the treatment of inflammation and autoimmune disorders.

  化合物（I）的公式被用于治疗炎症和自身免疫性疾病。
• Substituted Benzene Compounds
  申请人：EPIZYME, INC.

  公开号：US20160031907A1

  公开（公告）日：2016-02-04

  The present invention relates to compounds of Formula (I), wherein the variables are as defined herein. Pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof are disclosed.

  本发明涉及式(I)的化合物，其中变量如本文所定义。本发明还揭示了含有这些化合物的药物组合物以及通过将这些化合物和药物组合物用于需要治疗癌症的受试者的方法。
• SUBSTITUTED BENZENE COMPOUNDS
  申请人：EPIZYME, INC.

  公开号：US20160194316A1

  公开（公告）日：2016-07-07

  The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及取代苯化合物。本发明还涉及含有这些化合物的制药组合物以及通过将这些化合物和制药组合物用于需要治疗的受试者来治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的用途。