2-nonylchromen-4-one | 97139-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-nonylchromen-4-one
• CAS: 97139-88-3
• 化学式: C₁₈H₂₄O₂
• 分子量: 272.387
• InChiKey: NEGYZPOMBHWNIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-Hydroxy-phenyl)-dodecane-1,3-dione 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 生成 2-nonylchromen-4-one
  参考文献：
  名称：

  A Convenient Synthesis of 2- and 2,3-Substituted 4H-Chromen-4-ones

  摘要：

  DOI：

  10.1055/s-1984-31089

文献信息

• Efficient Assembly of Chromone Skeleton from 2,3-Allenoic Acids and Benzynes
  作者：Guobi Chai、Youai Qiu、Chunling Fu、Shengming Ma

  DOI：10.1021/ol202076c

  日期：2011.10.7

  Chromone derivatives were synthesized from 2,3-allenoic acids and benzynes in moderate to excellent yields under mild conditions. Instead of the cyclic conjugate addition of the intermediate A formed by the nucleophilic addition of allenoic acid with benzyne, this intermediate undergoes 1,2-addition with the carbonyl group, which was followed by the ring opening, conjugate addition, and protonolysis

  在温和的条件下，由2,3-烯丙基酸和苯并炔以中等至极好的收率合成了色酮衍生物。取代通过烯丙基酸与苯炔的亲核加成反应形成的中间体A的环状共轭加成，该中间体与羰基进行1,2-加成，然后开环，共轭加成和质子分解得到色酮衍生品。由于2,3-烯基酸和苯炔的取代基负载能力，该协议允许多样性。
• A ‘one pot’ synthesis of 2‐aryl‐4 <i>H</i> ‐1‐benzopyran‐4‐ones under coupled microwave phase transfer catalysis (PTC) and ultrasonic irradiation PTC
  作者：Vijai N. Pathak、Bindu Varshney、Ragini Gupta

  DOI：10.1002/jhet.5570450246

  日期：2008.3

  A ‘one pot’ synthesis of 2-aryl-4H-1-benzopyran-4-ones (3a-3f) is being reported. A mixture of o-hydroxyacetophenone, aroyl chloride, powdered n-tetrabutylammonium hydrogensulphate (n-TBAHSO4) and potassium hydroxide (KOH) were either irradiated by microwaves or sonicated in an ultrasonic cleaning bath to afford flavones directly. On the contrary, conventional liquid-liquid Phase Transfer Catalysis

  据报道，“一锅”合成了2-芳基-4 H -1-苯并吡喃-4-酮（3a-3f）。将邻羟基苯乙酮，芳酰氯，粉状正四丁基硫酸氢铵（n- TBAHSO 4）和氢氧化钾（KOH）的混合物用微波照射或在超声清洗浴中超声处理，直接制得黄酮。与此相反，传统的液体-液体相转移催化（PTC）使用苯作为有机相和水KOH作为得到第一β二酮按照贝克-卡塔拉曼合成的第二阶段，其在环化p甲苯磺酸（p-TSA）在下一步中得到所需的黄酮。PTC与微波或超声结合显示出更高的收率，干净的反应条件需要更少的时间，并且后处理协议更容易。所有合成的化合物均以其质子磁共振（PMR），IR，FAB质量和元素分析为特征。
• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。
• METHOD FOR PRODUCING COMPOSITION CONTAINING HARDLY WATER-SOLUBLE AROMATIC COMPOUND
  申请人：Kao Corporation

  公开号：EP4032524A1

  公开（公告）日：2022-07-27

  To provide a new method for producing a composition containing a hardly water-soluble aromatic compound, the composition having outstanding hardly water-soluble aromatic compound. A method for producing a composition containing a hardly water-soluble aromatic compound, comprising: Step (1) of obtaining a hardly water-soluble aromatic compound solution 1, Step (1) comprising Step (1-1) of preparing a material for heating comprising (A) a hardly water-soluble aromatic compound, (B) a polyol, and (C) an aqueous medium, and Step (1-2) of obtaining a heated solution containing a hardly water-soluble aromatic compound by heating the material for heating at normal pressure at a temperature of less than 100°C; and Step (2) of obtaining a hardly water-soluble aromatic compound solution 2 by adding water to the hardly water-soluble aromatic compound solution 1 such that the hardly water-soluble aromatic compound solution 2 has a concentration of the (A) hardly water-soluble aromatic compound above a saturation solubility at 25°C, wherein, in Step (1), a content of a surfactant in the material for heating is 0.1 mass% or less and a content of the (A) hardly water-soluble aromatic compound in the material for heating is below a saturation solubility of the (A) hardly water-soluble aromatic compound in a solvent having the same composition at 25°C.

  提供一种生产含有难溶于水的芳香族化合物的组合物的新方法，该组合物具有突出的难溶于水的芳香族化合物。 一种生产含有难溶于水的芳香化合物的组合物的方法，包括 步骤(1)获得难溶于水的芳香族化合物溶液1，步骤(1)包括步骤(1-1)制备由(A)难溶于水的芳香族化合物、(B)多元醇和(C)水介质组成的加热用材料，以及步骤(1-2)通过在常压下以低于 100°C 的温度加热加热用材料，获得含有难溶于水的芳香族化合物的加热溶液；以及 步骤 (2) 通过向难溶于水的芳香族化合物溶液 1 中加水，使难溶于水的芳香族化合物溶液 2 中 (A) 难溶于水的芳香族化合物的浓度高于 25°C 时的饱和溶解度，获得难溶于水的芳香族化合物溶液 2，其中，在步骤 (1) 中，加热用材料中表面活性剂的含量为 0.1 质量％或更低，且加热材料中(A) 难溶于水的芳香族化合物的含量低于(A) 难溶于水的芳香族化合物在 25°C 时在成分相同的溶剂中的饱和溶解度。
• SKIN COMPOSITION FOR EXTERNAL USE
  申请人：Kao Corporation

  公开号：EP4104862A1

  公开（公告）日：2022-12-21

  Provided is a liquid skin external composition which allows a poorly water-soluble component to be applied to a skin in a liquid state. An assembly of fiber for use in production of a liquid skin external composition, the assembly of fiber comprising (a) a polymer soluble in water and an alcohol or a ketone in a content of 50 mass% or more and 98 mass% or less with respect to the whole assembly of fiber and (b) a poorly water-soluble component in a content of 2 mass% or more and 40 mass% or less with respect to the whole assembly of fiber.

  本发明提供了一种液态皮肤外用组合物，可将水溶性较差的成分以液态涂抹在皮肤上。 一种用于生产液态皮肤外用组合物的纤维组件，该纤维组件包括：(a) 可溶于水和醇或酮的聚合物，其含量占整个纤维组件的 50%（含）以上，98%（含）以下；(b) 水溶性差的成分，其含量占整个纤维组件的 2%（含）以上，40%（含）以下。