N-(3-chlorobenzyl)-4-[(4-hydroxyphenyl)thio]-N-methylbutanamide | 1229039-69-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-(3-chlorobenzyl)-4-[(4-hydroxyphenyl)thio]-N-methylbutanamide
• 英文别名: N-[(3-chlorophenyl)methyl]-4-(4-hydroxyphenyl)sulfanyl-N-methylbutanamide
• CAS: 1229039-69-3
• 化学式: C₁₈H₂₀ClNO₂S
• 分子量: 349.881
• InChiKey: QLAZNWRJIJFHRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-[(4-hydroxyphenyl)thio]butanoic acid 、 3-氯-N-甲基苄胺 生成 N-(3-chlorobenzyl)-4-[(4-hydroxyphenyl)thio]-N-methylbutanamide
  参考文献：
  名称：

  NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS

  摘要：

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。

  公开号：

  US20120022054A1

文献信息

• [EN] NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS<br/>[FR] NOUVEAUX DÉRIVÉS ARYLES SUBSTITUÉS, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES EN TANT QU'AGENTS ANTI-VIH
  申请人：CELLVIR

  公开号：WO2010066847A1

  公开（公告）日：2010-06-17

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.

  本发明涉及新型取代芳基衍生物，其制备方法以及用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。
• Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
  申请人：Cellvir

  公开号：EP2196453A1

  公开（公告）日：2010-06-16

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting integration and for treating viral diseases or disorders such as HIV.

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制整合和治疗病毒性疾病或紊乱（如艾滋病毒）的用途。
• NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS
  申请人：Benarous Richard

  公开号：US20120022054A1

  公开（公告）日：2012-01-26

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。