N-[(1,3-dioxoisoindol-2-yl)methyl]-N-phenylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(1,3-dioxoisoindol-2-yl)methyl]-N-phenylbenzamide
• 化学式: C₂₂H₁₆N₂O₃
• 分子量: 356.4
• InChiKey: MALMJUYPDOCJAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
  申请人：Welsh William J.

  公开号：US20100152271A1

  公开（公告）日：2010-06-17

  A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and OR a ; R2 is selected from H, OH, and (C═O)(C 1-7 )alkyl; R a is (C 1-7 )alkyl or (C═O)(C 1-7 )alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.
• US7989487B2
  申请人：——

  公开号：US7989487B2

  公开（公告）日：2011-08-02
• US8455537B2
  申请人：——

  公开号：US8455537B2

  公开（公告）日：2013-06-04