4-(2,6-dimethylphenyl)benzophenone | 1067883-66-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,6-dimethylphenyl)benzophenone
• 英文别名: (2',6'-dimethylbiphenyl-4-yl)phenyl-methanone；[4-(2,6-Dimethylphenyl)phenyl]-phenylmethanone
• CAS: 1067883-66-2
• 化学式: C₂₁H₁₈O
• 分子量: 286.373
• InChiKey: MHAPLFPPKZWLEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-benzoylphenyl methanesulfonate 、 2,6-二甲基苯硼酸 在 potassium phosphate 、 C₅₈H₇₂N₂O₄P₂Pd₂ 作用下， 以 叔丁醇 为溶剂， 反应 3.0h， 以93%的产率得到4-(2,6-dimethylphenyl)benzophenone
  参考文献：
  名称：

  芳基甲磺酸酯的一般钯催化的Suzuki-Miyaura偶联。

  摘要：

  DOI：

  10.1002/anie.200803193

文献信息

• Remarkably Effective Phosphanes Simply with a PPh₂Moiety: Application to Pd-Catalysed Cross-Coupling Reactions for Tetra-<i>ortho</i>-substituted Biaryl Syntheses
  作者：Chau Ming So、Wing Kin Chow、Pui Ying Choy、Chak Po Lau、Fuk Yee Kwong

  DOI：10.1002/chem.201000723

  日期：2010.7.19

  Expanding the horizons of ArPPh2: New applications of triarylphosphane ligands are presented. The Pd–L1 and Pd–L2 complexes offer exceptionally high activity in Suzuki–Miyaura cross‐couplings of aryl chlorides. The extremely congested synthesis of tetra‐ortho‐substituted biaryl compounds is achieved for the first time by simply using triarylphosphane ligands.

  扩展ArPPh 2的视野：提出了三芳基膦配体的新应用。Pd– L1和Pd– L2络合物在Suzuki-Miyaura芳基氯化物的交叉偶联中具有极高的活性。仅通过使用三芳基膦配体，就可以实现四邻位取代的联芳基化合物的极为拥挤的合成。
• Suzuki−Miyaura Coupling of Aryl Tosylates Catalyzed by an Array of Indolyl Phosphine−Palladium Catalysts
  作者：Chau Ming So、Chak Po Lau、Albert S. C. Chan、Fuk Yee Kwong

  DOI：10.1021/jo8014819

  日期：2008.10.3

  A family of indolyl phosphine ligands was applied to Suzuki-Miyaura cross-coupling of aryl tosylates. Catalyst loading can be reduced to 0.2 mol % for coupling of nonactivated aryl tosylate. A challenging example for room temperature coupling is realized. The scope of this highly active Pd/L2 system can be extended to other boron nucleophiles, including trifluoroborate salts and boronate esters. The ligand structural comparisons toward the reactivity in tosylate couplings are also described.
• Ligands for transition-metals and methods of use
  申请人：Kwong Fuk Yee

  公开号：US20090326243A1

  公开（公告）日：2009-12-31

  The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture.
• US8212056B2
  申请人：——

  公开号：US8212056B2

  公开（公告）日：2012-07-03
• A General Palladium-Catalyzed Suzuki-Miyaura Coupling of Aryl Mesylates
  作者：Chau Ming So、Chak Po Lau、Fuk Yee Kwong

  DOI：10.1002/anie.200803193

  日期：2008.10.6