3-[[2-[6-Ethyl-2-(3-methylphenyl)quinazolin-4-yl]sulfanylacetyl]amino]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[[2-[6-Ethyl-2-(3-methylphenyl)quinazolin-4-yl]sulfanylacetyl]amino]benzoic acid
• 化学式: C₂₆H₂₃N₃O₃S
• 分子量: 457.5
• InChiKey: WAJODMSPKFZONU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ANT-LIGANDS MOLECULES AND BIOLOGICAL APPLICATIONS
  申请人：Borgne-Sanchez Annie

  公开号：US20110086865A1

  公开（公告）日：2011-04-14

  The invention relates to molecules ANT-ligands having a substituted nitrogeneous heterocycle A wherein —A is a substituted pyrazinone of formula I wherein R1 is —(CH 2 ) n —CO—OH; —(CH 2 ) n —CO—OR; —(CH 2 ) n —CO—NHR; —(CH 2 ) n —CO—N(R, R′); —(CH 2 ) n —OH; —(CH 2 ) n —OR; —(CH 2 ) n —OAr; —(CH 2 ) n —C(R,R′) —(CH 2 ) n —OH, R and R′, in the above radicals, being identical or different and representing H or a C1-C12 alkyl or cycloalkyl radical; and Ar is a phenyl or Het., Het. representing an heterocyclic radical with one or several hetero atoms selected between N, S and O, said phenyl or heterocycle being optionally substituted by one or several atoms, groups or radicals selected from halogen atoms such as Cl, Br, I, or halogenated groups such as —CCl 3 or —CF 3 ; one or several —OH, —OR, —COOH or —COOR groups; a phenyl; a linear or branched C1-C12 alkyl radical; —NH—COR; or —CN; said groups occupying the same or different positions on the phenyl or heterocyclic radical; a linear or branched C1-C12 alkyl radical; a linear or branched C2-C12 alkylene radical; —(CH 2 ) n —C3-C6 cycloalkyl radical; —(CH 2 ) n Ar or —(CH 2 ) n Het.; —(CH 2 ) n —NH—CO—R; —(CH 2 ) n —NH 2 ; —(CH 2 ) n —N(R,R′); —(CH 2 ) n —NH—CO—OH; —(CH 2 ) n —NH—CO—OR; —NH—(CH 2 ) n —CO—OH; —NH—(CH 2 ) n —CO—OR; R2 is —(CH 2 ) n -Ar, Ar being such as above defined and being optionally substituted such as above defined; a linear or branched C1-C12 alkyl or C2-C12 alkylene radical with one or several double bonds; —(CH 2 ) n —OH; —(CH 2 ) n —OR; —(CH 2 ) n —CO—Het; —(CH 2 ) n —NH—CO—R; —(CH 2 ) n —NH 2 ; —(CH 2 ) n —N(R,R′); —(CH 2 ) n —CO—OH; —(CH 2 ) n —CO—OR; a linear or branched C1-C12 alkyl radical; —(CH 2 ) n —C(R)=CH—C (R)=CH 2 , R3 forms a phenyl or an heterocyclic condensed group with the two adjacent carbons of the pyrazinone residue, said condensed group being optionally substituted such as above defined for Ar and Het.; and/or condensed to a cyclohexyl or oxanyl group, in turn optionally substituted such as above defined for Ar; n is 0 or an integer from 1 to 5; or A is a substituted pyrazine of formula II wherein R 4 is a —CO—NH—Ar radical, optionally substituted such as above defined; R5 forms a phenyl or heterocyclic group condensed to the two adjacent carbon groups of the pyrazine residue, said phenyl or heterocyclic group being optionally substituted such as above defined, and Ar being such as above defined with respect to formula I or A is a substituted pyridine group of formula III wherein, Ar and R2 are as above defined with respect to formula I.

  该发明涉及具有取代氮杂环A的分子ANT配体，其中—A是具有以下式I的取代吡嗪酮：其中R1是—(CH2)n—CO—OH;—( )n—CO—OR;—( )n—CO—NHR;—( )n—CO—N(R, R′);—( )n—OH;—( )n—OR;—( )n—OAr;—( )n—C(R,R′)—( )n—OH，上述基团中的R和R′相同或不同，代表H或C1-C12烷基或环烷基基团；Ar是苯基或Het.，Het.代表一个杂原子为N、S和O的杂环基团，所述苯基或杂环基团可以选择性地被一个或多个原子、基团或基团取代，所选基团包括卤原子如Cl、Br、I，或卤代基团如—CCl3或—CF3；一个或多个—OH、—OR、—COOH或—COOR基团；苯基；线性或支链的C1-C12烷基基团；—NH—COR；或—CN；这些基团可以占据苯基或杂环基团上的相同或不同位置；线性或支链的C1-C12烷基基团；线性或支链的C2-C12亚烯基基团；—( )n—C3-C6环烷基基团；—( )nAr或—( )nHet.；—( )n—NH—CO—R；—( )n—NH2；—( )n—N(R,R′)；—( )n—NH—CO—OH；—( )n—NH—CO—OR；—NH—( )n—CO—OH；—NH—( )n—CO—OR；R2是—( )n-Ar，Ar如上定义，可以选择性地被如上定义取代；线性或支链的C1-C12烷基或C2-C12亚烯基基团，带有一个或多个双键；—( )n—OH；—( )n—OR；—( )n—CO—Het；—( )n—NH—CO—R；—( )n—NH2；—( )n—N(R,R′)；—( )n—CO—OH；—( )n—CO—OR；线性或支链的C1-C12烷基基团；—( )n—C(R)=CH—C(R)= ；R3形成一个苯基或与吡嗪酮残基的两个相邻碳原子形成杂环的紧凑基团，所述紧凑基团可以选择性地被如上定义的Ar和Het取代；和/或紧凑为一个环己基或氧杂环基团，进一步可以选择性地被如上定义的Ar取代；n为0或1到5的整数；或A是具有以下式II的取代吡嗪：其中R4是一个—CO—NH—Ar基团，可以选择性地被如上定义取代；R5形成一个苯基或杂环基团，紧凑到吡嗪残基的两个相邻碳基团，所述苯基或杂环基团可以选择性地被如上定义取代，Ar如上定义，关于式I的定义；或A是具有以下式III的取代吡啶基团：其中，Ar和R2如上定义，关于式I的定义。
• US8809346B2
  申请人：——

  公开号：US8809346B2

  公开（公告）日：2014-08-19
• US9657031B2
  申请人：——

  公开号：US9657031B2

  公开（公告）日：2017-05-23
• [EN] ANTI-LIGANDS MOLECULES AND BIOLOGICAL APPLICATIONS<br/>[FR] MOLÉCULES ANTI-LIGANDS ET APPLICATIONS BIOLOGIQUES
  申请人：MITOLOGICS

  公开号：WO2009144584A1

  公开（公告）日：2009-12-03

  The invention relates to molecules ANT-ligands having a substituted nitrogeneous heterocycle A wherein - A is a substituted pyrazinone of formula I, or - A is a substituted pyrazine of formula II, or A is a substituted pyridine group of formula III.