5-氟咪唑并[1,2-a]吡啶-2-甲醛 | 878197-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 中文名称: 5-氟咪唑并[1,2-a]吡啶-2-甲醛
• 中文别名: 5-氟咪唑并[1,2-A]吡啶-2-甲醛
• 英文名称: 5-fluoroimidazo[1,2-a]pyridine-2-carbaldehyde
• 英文别名: 5-fluoro-imidazol[1,2-a]pyridine-2-carbaldehyde
• CAS: 878197-67-2
• 化学式: C₈H₅FN₂O
• mdl: MFCD11656369
• 分子量: 164.139
• InChiKey: ANTIOTRWBFOORM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5-氟咪唑并[1,2-a]吡啶-2-甲醛 在 sodium tetrahydroborate 、 水 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以93%的产率得到(5-fluoroimidazo[1,2-a]pyridin-2-yl)methanol
  参考文献：
  名称：

  WO2006/76131

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(dichloromethyl)-5-fluoroimidazo[1,2-a]pyridine 在 水 、 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以55%的产率得到5-氟咪唑并[1,2-a]吡啶-2-甲醛
  参考文献：
  名称：

  Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

  摘要：

  Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.056

文献信息

• [EN] VIRAL REPLICATION INHIBITORS<br/>[FR] INHIBITEURS DE REPLICATION VIRALE
  申请人：UNIV LEUVEN KATH

  公开号：WO2013045516A1

  公开（公告）日：2013-04-04

  The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

  本发明涉及一系列新化合物，通过使用这些新化合物来预防或治疗动物的病毒感染的方法，以及将这些新化合物用作药物，更好地用于治疗或预防病毒感染，特别是感染RNA病毒，更特别是感染属于黄病毒科的病毒，更特别是感染登革病毒。本发明还涉及这些新化合物的药物组合或混合制剂，用作药物的组合或制剂，更好地用于预防或治疗病毒感染。该发明还涉及这些化合物的制备方法。
• [EN] NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF<br/>[FR] NOUVEAUX COMPOSÉS MODULANT LE RÉCEPTEUR SENSIBLE AU CALCIUM, ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：LEO PHARMA AS

  公开号：WO2010136037A1

  公开（公告）日：2010-12-02

  The invention relates to novel calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

  该发明涉及一种表示为公式I的新型调节钙感受受体（CaSR）的取代环戊烯化合物及其衍生物，该化合物用作药物，用于治疗的化合物，包含该化合物的制药组合物，使用该化合物治疗疾病的方法以及使用该化合物制造药物。
• Chemical Compounds
  申请人：Gudmundsson Kristian

  公开号：US20070232615A1

  公开（公告）日：2007-10-04

  The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to a chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a target cell.

  本发明提供了一种新型化合物，它们以一种与趋化因子受体结合的方式对目标细胞表现出对HIV感染的保护作用，并影响天然配体或趋化因子与目标细胞的CXCR4等受体的结合。
• CHEMICAL COMPOUNDS
  申请人：GUDMUNDSSON Kristjan

  公开号：US20070254910A1

  公开（公告）日：2007-11-01

  The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to a chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a target cell.

  本发明提供了一种新型化合物，它们以一种与趋化因子受体结合的方式对靶细胞表现出对HIV感染的保护作用，并影响自然配体或趋化因子与靶细胞的CXCR4等受体的结合。
• NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF
  申请人：Nørremark Bjarne

  公开号：US20120122784A1

  公开（公告）日：2012-05-17

  The invention relates to novel calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

  该发明涉及一种新型的钙感受受体（CaSR）调节代替环戊烯化合物，其在式I中表示及其衍生物，以及将该化合物用作药物的方法，将该化合物用于治疗的方法，包含该化合物的制药组合物，使用该化合物治疗疾病的方法，以及将该化合物用于制造药物的用途。