Buchwald-Hartwig Aminations of Aryl Chlorides: A Practical Protocol Based on Commercially Available Pd(0)-NHC Catalysts
作者:L. J. Gooßen、A. Rivas-Nass、J. Paetzold、O. Briel、R. Karch、B. Kayser
DOI:10.1055/s-2004-837205
日期:——
naphthoquinone imidazolin-2-ylidene-palladium(0) complexes were found to be highly active one-component catalysts for the amination of aryl halides. With these very robust catalysts, the expensive bases Cs 2 CO 3 or NaOt-Bu traditionally used can be replaced by KOH. A convenient reaction protocol has been developed for the coupling of a wide range of aryl chlorides with primary or secondary amines.
发现市售的、空气和水稳定的萘醌咪唑啉-2-亚基-钯 (0) 配合物是用于芳基卤化物胺化的高活性单组分催化剂。使用这些非常坚固的催化剂,传统上使用的昂贵碱 Cs 2 CO 3 或 NaOt-Bu 可以被 KOH 代替。已经开发了一种方便的反应方案,用于将各种芳基氯化物与伯胺或仲胺偶联。