5-氧代-5-[(4-乙烯基苄基)氧基]戊酸 | 139441-07-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氧代-5-[(4-乙烯基苄基)氧基]戊酸
• 中文别名: N,N-二丙基-4-碘苯基-N-甲基铵
• 英文名称: mono-p-vinylbenzyl glutarate
• 英文别名: 5-[(4-Ethenylphenyl)methoxy]-5-oxopentanoic acid
• CAS: 139441-07-9
• 化学式: C₁₄H₁₆O₄
• 分子量: 248.279
• InChiKey: OFQRMXHMNVKBGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (4-乙烯基苯基)甲醇 、 5,5'-氧双(5-氧代戊酸) 在 2-二甲氨基吡啶 作用下， 以 氯仿 为溶剂， 生成 5-氧代-5-[(4-乙烯基苄基)氧基]戊酸
  参考文献：
  名称：

  Carboxy containing monomers

  摘要：

  某些具有反应性羧基的乙烯基不饱和可聚合单体对于制备用于多种用途的同聚物和共聚物是有用的，包括诊断分析。聚合物可以以乳胶粒的形式在水性配方中提供。这些单体由以下结构表示：##STR1## 其中：R是氢、卤素或1到3个碳原子的烷基，M是氢、碱金属离子或铵离子，L是一个连接基团，其连接链中有8到50个原子，并包含两个或多个二价烃基团，这些基团通过一个或多个氮、氧或硫原子连接或终止，或者通过连接链中含有一个或多个这样的原子的一个或多个基团，前提是L至少含有一个不是直接连接到端部##STR2##基团的芳基，并且进一步提供，没有任何烃基团具有非芳香不饱和度。

  公开号：

  US05210289A1

文献信息

• Carboxy containing monomers
  申请人：Eastman Kodak Company

  公开号：US05210289A1

  公开（公告）日：1993-05-11

  Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: ##STR1## wherein: R is hydrogen, halo or alkyl of 1 to 3 carbon atoms, M is hydrogen, an alkali metal ion or an ammonium ion, and L is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal ##STR2## group, and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.

  某些具有反应性羧基的乙烯基不饱和可聚合单体对于制备用于多种用途的同聚物和共聚物是有用的，包括诊断分析。聚合物可以以乳胶粒的形式在水性配方中提供。这些单体由以下结构表示：##STR1## 其中：R是氢、卤素或1到3个碳原子的烷基，M是氢、碱金属离子或铵离子，L是一个连接基团，其连接链中有8到50个原子，并包含两个或多个二价烃基团，这些基团通过一个或多个氮、氧或硫原子连接或终止，或者通过连接链中含有一个或多个这样的原子的一个或多个基团，前提是L至少含有一个不是直接连接到端部##STR2##基团的芳基，并且进一步提供，没有任何烃基团具有非芳香不饱和度。
• Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0462644A1

  公开（公告）日：1991-12-27

  Biologically active reagents are prepared from particles of copolymers having highly reactive carboxy or equivalent groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through highly reactive carboxy groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents.

  生物活性试剂由具有高活性羧基或等效基团的共聚物颗粒制备而成。制备试剂的方法是将生物活性物质（如抗体）直接或间接地通过颗粒表面的高活性羧基共价连接到颗粒上。这些试剂可用于分析元件、检测特定结合配体（如免疫物种）的方法和免疫测定，也可作为亲和层析试剂用于纯化方法。
• Carboxy containing monomers and polymers and latices prepared from same
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0466220A2

  公开（公告）日：1992-01-15

  Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: wherein: R is hydrogen, halo or alkyl of 1 to 3 carbon atoms, M is hydrogen, an alkali metal ion or an ammonium ion, and L is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal group, and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.

  某些具有活性羧基的乙烯不饱和可聚合单体可用于制备各种用途的均聚物和共聚物，包括诊断检测。这些聚合物可以作为水性组合物中的胶乳颗粒供应。单体的结构如下： 其中 R 是氢、卤素或 1 至 3 个碳原子的烷基、 M 是氢、碱金属离子或铵离子，以及 L 是一个连接基团，其连接链中有 8 至 50 个原子，由两个或两个以上的二价烃基团组成，连接基团用一个或多个氮、氧或硫原子连接或终止，或在连接链中用一个或多个含有这些原子的基团连接或终止，条件是 L 至少有一个芳基不与末端直接连接。 L 具有至少一个与末端基团不直接相连的芳基，而且没有一个烃基具有非芳香族不饱和性。
• Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to caboxylated particles & a kit containing same
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0462670B1

  公开（公告）日：1996-08-21
• Biologically active reagent, analytical element and methods for use of the reagent
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0468585B1

  公开（公告）日：1995-11-08