2-Amino-2',4'-dimethyl-biphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-2',4'-dimethyl-biphenyl
• 英文别名: 2',4'-Dimethyl[1,1'-biphenyl]-2-ylamine；2-(2,4-dimethylphenyl)aniline
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: MGNPOCXTUXYIFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• OPIOID RECEPTOR MODULATORS AND USE THEREOF
  申请人：National Health Research Institutes

  公开号：US20170056377A1

  公开（公告）日：2017-03-02

  Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.

  揭示了一种体外筛选方法，用于识别μ-阿片受体的拮抗剂-激动剂异位调节剂，并揭示了一种体内方法，用于确认测试化合物是否为μ-阿片受体的这种调节剂。还揭示了一种使用式（I）化合物和含有该化合物的药物组合物治疗阿片受体相关疾病的方法。
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3461830A1

  公开（公告）日：2019-04-03

  An organometallic compound represented by Formula 1: wherein, in Formula 1, groups and variables are the same as described in the specification.

  由式 1 表示的有机金属化合物： 其中，式 1 中的基团和变量与说明书中描述的相同。
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3722301A1

  公开（公告）日：2020-10-14

  An organometallic compound represented by Formula 1, an organic light-emitting device including the organometallic compound, and a diagnostic composition including the organometallic compound:          Formula 1     M(L1)n1(L2)n2, wherein, in Formula 1, M, L1, L2, n1, and n2 are each described herein.

  一种由式 1 表示的有机金属化合物、一种包括该有机金属化合物的有机发光器件，以及一种包括该有机金属化合物的诊断组合物： 式 1 M(L1)n1(L2)n2、 其中，在式 1 中，M、L1、L2、n1 和 n2 分别如本文所述。
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING SAME, AND DIAGNOSTIC COMPOSITION INCLUDING SAME
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3772517A1

  公开（公告）日：2021-02-10

  An organometallic compound represented by Formula 1, wherein M1 is beryllium, magnesium, aluminum, calcium, titanium, manganese, cobalt, copper, zinc, gallium, germanium, zirconium, ruthenium, rhodium, palladium, silver, rhenium, platinum, or gold; A1 to A3 are each independently a C5-C30 carbocyclic group or a C1-C30 heterocyclic group; A4 is a 5-membered heterocyclic group; A5 is a C7-C30 carbocyclic group of at least two rings comprising a 6-membered carbocyclic group, or A5 is a C1-C30 heterocyclic group of at least two rings comprising a 6-membered carbocyclic group or a 6-membered heterocyclic group; X10, X20, X30, and X40 to X44 are each independently C or N; T1 to T3 are each independently a single bond, *-N[(L1)a1-(R1)b1]-*', *-B(R1)-*', *-P(R1)-*', *-C(R1)(R2)-*', *-Si(R1)(R2)-*', *-Ge(R1)(R2)-*', *-S-*', *-Se-*', *-O-*', *-C(=O)-*', *-S(=O)-*', *-S(=O)2-*', *-C(R1)=C(R2)-*', *-C(=S)-*', or *-C≡C-*'; and wherein the other substituents may be understood by referring to the detailed description.

  一种由式1表示的有机金属化合物，其中M1是铍、镁、铝、钙、钛、锰、钴、铜、锌、镓、锗、锆、钌、铑、钯、银、铼、铂或金；A1至A3各自独立地是C5-C30碳环基团或C1-C30杂环基团；A4 是 5 元杂环基团； A5 是至少由两个环组成的 C7-C30 碳环基团，其中包括一个 6 元碳环基团，或 A5 是至少由两个环组成的 C1-C30 杂环基团，其中包括一个 6 元碳环基团或一个 6 元杂环基团；X10、X20、X30 和 X40 至 X44 各自独立地为 C 或 N；T1 至 T3 各自独立地为单键、*-N[(L1)a1-(R1)b1]-*'、*-B(R1)-*'、*-P(R1)-*'、*-C(R1)(R2)-*'、*-Si(R1)(R2)-*'、*-Ge(R1)(R2)-*'、*-S-*'、*-Se-*'、*-O-*'、*-C(=O)-*'、*-S(=O)-*'、*-S(=O)2-*'、*-C(R1)=C(R2)-*'、*-C(=S)-*'或*-C≡C-*'；其中其他取代基可参阅详细说明。
• COMPOSITION AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3761385A1

  公开（公告）日：2021-01-06

  A composition including a platinum-containing organometallic compound, a first compound, a second compound, and a third compound, and an organic light-emitting device including the same wherein the composition does not comprise iridium, the platinum-containing organometallic compound, the first compound, the second compound, and the third compound are different from each other, the first compound comprises at least one electron transport moiety, the second compound and the third compound do not include a metal, each of an absolute value of a HOMO energy level of the second compound and an absolute value of a HOMO energy level of the third compound is 5.30 eV to 5.85 eV, the difference between the absolute value of the HOMO energy level of the second compound and the absolute value of the HOMO energy level of the third compound is 0.01 eV to 0.30 eV.

  一种包括含铂有机金属化合物、第一化合物、第二化合物和第三化合物的组合物，以及包括该组合物的有机发光器件，其中该组合物不含铱、 含铂有机金属化合物、第一化合物、第二化合物和第三化合物彼此不同、 第一化合物包含至少一个电子传输分子、 第二化合物和第三化合物不包含金属、 第二种化合物的 HOMO 能级绝对值和第三种化合物的 HOMO 能级绝对值各为 5.30 eV 至 5.85 eV、 第二种化合物的 HOMO 能级绝对值与第三种化合物的 HOMO 能级绝对值之差为 0.01 eV 至 0.30 eV。