3-(2-Aminoethyl)-5-(2H-1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 3-(2-Aminoethyl)-5-(2H-1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione
• 英文别名: (5Z)-3-(2-aminoethyl)-5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione
• 化学式: C₁₃H₁₂N₂O₄S
• mdl: MFCD01209248
• 分子量: 292.31
• InChiKey: ZAWGHGDNVXQOKU-WDZFZDKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NON-ATP DEPENDENT INHIBITORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)
  申请人：Shapiro Paul S.

  公开号：US20140179743A1

  公开（公告）日：2014-06-26

  A compound, having the formula A-1: Wherein R 1 and R 2 are defined herein. Methods of using the compound and compositions containing the compound are provided.

  一个具有化学式A-1的化合物，其中R1和R2在此处被定义。提供了使用该化合物的方法和含有该化合物的组合物。
• TREATMENT OF SQUAMOUS CELL CARCINOMAS WITH INHIBITORS OF ERK
  申请人：Kura Oncology, Inc.

  公开号：US20190192517A1

  公开（公告）日：2019-06-27

  The present disclosure provides methods and systems for identifying and/or treating subjects having cancer, such as squamous cell carcinoma, who are more likely to respond to treatment with an ERK inhibitor.
• US9115122B2
  申请人：——

  公开号：US9115122B2

  公开（公告）日：2015-08-25
• [EN] TREATMENT OF ADENOCARCINOMAS WITH MAPK PATHWAY INHIBITORS<br/>[FR] TRAITEMENT D'ADÉNOCARCINOMES AVEC DES INHIBITEURS DE LA VOIE MAPK
  申请人：KURA ONCOLOGY INC

  公开号：WO2020046966A1

  公开（公告）日：2020-03-05

  The present disclosure provides methods and systems for identifying and/or treating subjects having cancer, such as adenocarcinoma, who are more likely to respond to treatment with a MAPK pathway inhibitor.