(5Z)-5-[[5-(3-chlorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5Z)-5-[[5-(3-chlorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
• 化学式: C₁₄H₈ClNO₃S
• 分子量: 305.7
• InChiKey: ORRXLFZJXFPOJA-GHXNOFRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways
  申请人：Surolia Avadhesha

  公开号：US20080051445A1

  公开（公告）日：2008-02-28

  The current invention presents enoyl-ACP reductase, an enzyme of the type II fatty acid synthesis pathway as a target for treating human malarias and other infectious diseases. We also present in the current invention, 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents. We provide 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents either alone or in combination with other known antimicrobial and antimalarial agents with or without added adjuvants or diluents or carriers.