prop-2-enyl 6-[[(2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoyl]amino]hexanoate | 1026875-19-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: prop-2-enyl 6-[[(2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoyl]amino]hexanoate
• CAS: 1026875-19-3
• 化学式: C₃₀H₃₉N₃O₅
• 分子量: 521.657
• InChiKey: OQCQPYFNNBFFCR-MHZLTWQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  38
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 、 芴甲氧羰酰基-6-氨基己酸 、 prop-2-enyl 6-[[(2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoyl]amino]hexanoate 以0.176 g的产率得到
  参考文献：
  名称：

  Large Cyclic Peptides as Cores of Multivalent Ligands:  Application to Inhibitors of Receptor Binding by Cholera Toxin

  摘要：

  Large cyclic decapeptides (up to 50-atom ring) were synthesized efficiently on the solid phase with allyl-ester protection of the carboxyl terminus during elongation. Pentavalent ligands, in a "core-linker-finger" modular setup, were assembled by using these cyclic peptide cores to demonstrate large affinity gains for inhibition of surface receptor binding by the cholera toxin B pentamer. The results suggest that the peptide cores retain expanded conformation in solution so that shorter flexible linkers are needed for larger peptide cores to achieve the best inhibitory results.

  DOI：

  10.1021/jo0489770
• 作为产物：
  描述：

  6-Amino-hexanoic acid allyl ester 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 1-羟基苯并三唑 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 prop-2-enyl 6-[[(2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoyl]amino]hexanoate
  参考文献：
  名称：

  Large Cyclic Peptides as Cores of Multivalent Ligands:  Application to Inhibitors of Receptor Binding by Cholera Toxin

  摘要：

  Large cyclic decapeptides (up to 50-atom ring) were synthesized efficiently on the solid phase with allyl-ester protection of the carboxyl terminus during elongation. Pentavalent ligands, in a "core-linker-finger" modular setup, were assembled by using these cyclic peptide cores to demonstrate large affinity gains for inhibition of surface receptor binding by the cholera toxin B pentamer. The results suggest that the peptide cores retain expanded conformation in solution so that shorter flexible linkers are needed for larger peptide cores to achieve the best inhibitory results.

  DOI：

  10.1021/jo0489770

文献信息

• Large Cyclic Peptides as Cores of Multivalent Ligands:  Application to Inhibitors of Receptor Binding by Cholera Toxin
  作者：Zhongsheng Zhang、Jiyun Liu、Christophe L. M. J. Verlinde、Wim G. J. Hol、Erkang Fan

  DOI：10.1021/jo0489770

  日期：2004.10.1

  Large cyclic decapeptides (up to 50-atom ring) were synthesized efficiently on the solid phase with allyl-ester protection of the carboxyl terminus during elongation. Pentavalent ligands, in a "core-linker-finger" modular setup, were assembled by using these cyclic peptide cores to demonstrate large affinity gains for inhibition of surface receptor binding by the cholera toxin B pentamer. The results suggest that the peptide cores retain expanded conformation in solution so that shorter flexible linkers are needed for larger peptide cores to achieve the best inhibitory results.