5-(3-Thienylmethylene)-2-thioxo-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-(3-Thienylmethylene)-2-thioxo-1,3-thiazolidin-4-one
• 英文别名: (5E)-2-sulfanylidene-5-(thiophen-3-ylmethylidene)-1,3-thiazolidin-4-one
• 化学式: C₈H₅NOS₃
• 分子量: 227.3
• InChiKey: XXEBTKBRSLSLSF-ZZXKWVIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PYRROLIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BETA-AMYLOID OR TAU PROTEIN-ASSOCIATED DISEASES CONTAINING SAME
  申请人：Yonsei University, University-Industry Foundation(UIF).

  公开号：EP4083037A1

  公开（公告）日：2022-11-02

  Provided are: a novel pyrrolidine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same and having the effects of inhibiting beta-amyloid and/or tau protein aggregation, and/or breaking down beta-amyloid and/or tau protein aggregates, and/or preventing and/or treating beta-amyloid and/or tau protein-associated diseases.

  本文提供了：一种新型吡咯烷衍生物或其药学上可接受的盐；以及一种含有该衍生物并具有抑制β-淀粉样蛋白和/或tau蛋白聚集和/或分解β-淀粉样蛋白和/或tau蛋白聚集和/或预防和/或治疗β-淀粉样蛋白和/或tau蛋白相关疾病的作用的药物组合物。
• COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE
  申请人：Fuzians Biomedicals, Inc.

  公开号：EP2590971A2

  公开（公告）日：2013-05-15
• [EN] RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS<br/>[FR] DERIVES DE RHODANINE UTILES POUR LE TRAITEMENT ET LA PREVENTION DE TROUBLES METABOLIQUES DES OS
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2000018748A1

  公开（公告）日：2000-04-06

  The object of the present invention are compounds of general formula (I), in which m signifies a number between 0 and 8; q signifies a number between 0 and 8; X signifies the group CH2 or C=S, whereby A signifies a single bond and m signifies 0 when X signifies CH2; A signifies a single or double bond; R1, R2 signify hydrogen or lower alkyl, whereby R1 and R2 can be the same or different and, when m signifies 2-8, R1 and R2 in the group CR1=CR2 can have various significances within the following sequence; R3 signifies hydrogen or lower alkyl; Z signifies oxygen, sulphur; W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain one or more hetero atoms, as well as their physiologically compatible salts, esters, optically active forms, racemates, tautomers, as well as derivatives which can be metabolized in vivo to compounds of general formula (I), as well as the use of these compounds for the production of medicaments for the prophylaxis or therapy of metabolic bone disorders.
• [EN] COMPOUNDS USEFUL AS ANTIVIRAL AGENTS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] COMPOSÉS UTILES EN TANT QU'AGENTS ANTIVIRAUX, COMPOSITIONS, ET PROCÉDÉS D'UTILISATION
  申请人：FUZIANS BIOMEDICALS INC

  公开号：WO2011160024A2

  公开（公告）日：2011-12-22

  Novel 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives that are effective for use in treating viral infections are described. Also described are pharmaceutical compositions comprising the 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives and methods for using the compounds or compositions.
• [EN] PYRROLIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BETA-AMYLOID OR TAU PROTEIN-ASSOCIATED DISEASES CONTAINING SAME<br/>[FR] DÉRIVÉ DE PYRROLIDINE ET COMPOSITION PHARMACEUTIQUE DE PRÉVENTION OU DE TRAITEMENT DE MALADIES ASSOCIÉES À LA PROTÉINE BÊTA-AMYLOÏDE OU TAU CONTENANT CE DERNIER<br/>[KO] 피롤리딘 유도체 및 이를 포함하는 베타-아밀로이드 또는 타우 단백질 관련 질병의 예방 또는 치료용 약학 조성물
  申请人：YONSEI UNIV UNIV INDUSTRY FOUNDATION UIF

  公开号：WO2021133037A1

  公开（公告）日：2021-07-01

  신규한 피롤리딘 유도체 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 베타-아밀로이드 및/또는 타우 단백질의 응집 억제 및/또는 베타-아밀로이드 및/또는 타우 단백질의 응집체 분해, 및/또는 베타-아밀로이드 및/또는 타우 단백질 관련 질병의 예방 및/또는 치료 효과를 갖는 약학 조성물이 제공된다.