4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-methylphenyl)-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-methylphenyl)-1,3-thiazol-2-amine
• 化学式: C₁₆H₁₄N₄S₂
• 分子量: 326.4
• InChiKey: YPEJXZAEZXYWAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  98.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
  申请人：Mao Long

  公开号：US20110207751A1

  公开（公告）日：2011-08-25

  Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

  本发明揭示了一种具有嵌合的双环杂环芳香环系统，且用噻唑环取代的新化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。这些化合物的功效通过一种监测细胞生长/迁移的系统得到证明，该系统显示它们是癌细胞生长和/或迁移的有效抑制剂。此外，本发明的化合物已被证明能够停止体内肿瘤的生长，并减小体内肿瘤的大小。本发明还揭示了包含这些化合物的组合物，以及使用这些化合物和组合物治疗癌症的方法。
• NOVEL ANTIPRION COMPOUNDS
  申请人：The Regents of the University of California

  公开号：US20140329863A1

  公开（公告）日：2014-11-06

  Described herein are novel compositions and methods of treatment addressing diseases such as neurodegenerative diseases, including prion diseases and Alzheimer's disease.

  本文描述了一种新的组合物和治疗方法，用于治疗神经退行性疾病，包括朊病和阿尔茨海默病。
• [EN] HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS UTILISATIONS EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：ACEA BIOSCIENCES INC

  公开号：WO2011103509A1

  公开（公告）日：2011-08-25

  Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.