ethyl 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate
• 化学式: C₁₅H₁₅NO₅S₂
• 分子量: 353.4
• InChiKey: QHPJWPQRZMBKTG-KPKJPENVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• COMBINATIONS COMPRISING AN INHIBITOR OF AN ANTI-APOPTOTIC PROTEIN, SUCH AS BCL-2, BCL-XL, BCLW OR MCL-1, AND A NOTCH SIGNALING PATHWAY INHIBITOR FOR TREATING CANCER
  申请人：Cellestia Biotech AG

  公开号：EP4008324A1

  公开（公告）日：2022-06-08

  The present invention relates to pharmaceutical combinations comprising an inhibitor of an anti-apoptotic protein and a NOTCH signaling pathway inhibitor and their use in a method for the prevention, delay of progression or treatment of cancer in a subject.

  本发明涉及由抗凋亡蛋白抑制剂和 NOTCH 信号通路抑制剂组成的药物组合及其在预防、延缓或治疗受试者癌症的方法中的用途。
• [EN] PHARMACEUTICAL COMBINATIONS FOR TREATING CANCER<br/>[FR] COMBINAISONS PHARMACEUTIQUES POUR LE TRAITEMENT DU CANCER
  申请人：[en]CELLESTIA BIOTECH AG

  公开号：WO2022122667A1

  公开（公告）日：2022-06-16

  The present invention relates to pharmaceutical combinations comprising an inhibitor of an anti-apoptotic protein and a NOTCH signaling pathway inhibitor and their use in a method for the prevention, delay of progression or treatment of cancer in a subject.
• [EN] METHOD FOR TREATING AN AUTOIMMUNE AND INFLAMMATORY DISEASE<br/>[FR] PROCÉDÉ DE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE ET INFLAMMATOIRE
  申请人：[en]CELLESTIA BIOTECH AG

  公开号：WO2022253794A2

  公开（公告）日：2022-12-08

  The present invention relates to methods for the prevention, delay of progression or treatment of an autoimmune and inflammatory disease (AIID) in a subject.