1-tert-butyl-3-nitroazetidine | 125735-36-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: 1-tert-butyl-3-nitroazetidine
• 英文别名: 1-(Tert-butyl)-3-nitroazetidine
• CAS: 125735-36-6
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: IGUKDRVXMHIIMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-tert-butyl-3-nitroazetidine 在 sodium hydroxide 、 sodium persulfate 、 potassium hexacyanoferrate(III) 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 1.0h， 以60%的产率得到1-(2-甲基-2-丙基)-3,3-二硝基吖丁啶
  参考文献：
  名称：

  Synthesis and x-ray crystal structure of 1,3,3-trinitroazetidine

  摘要：

  DOI：

  10.1021/jo00296a066
• 作为产物：
  描述：

  1-(tert-butyl)azetidin-3-yl methanesulfonate 在 间苯三酚 、 sodium nitrite 作用下， 以 甲醇 、 水 为溶剂， 反应 16.0h， 以8%的产率得到1-tert-butyl-3-nitroazetidine
  参考文献：
  名称：

  Synthesis and x-ray crystal structure of 1,3,3-trinitroazetidine

  摘要：

  DOI：

  10.1021/jo00296a066

文献信息

• 1-GLYCIDYL-3,3-DINITROAZETIDINE CONTAINING EXPLOSIVE MOIETY AND PREPARATION METHOD THEREOF
  申请人：KOWN Young-Hwan

  公开号：US20090299079A1

  公开（公告）日：2009-12-03

  Disclosed is a 1-glycidyl-3,3-dinitroazetidine(GDNAZ) of Formula I wherein dinitroazetidine group which is a high energy group having unit structure of explosive moiety is incorporated to a monomer, and the method thereof. By using the GDNAZ of the present invention in the synthesis of energetic binder for high-performance insensitive explosive, an energetic binder with enhanced thermal and storing stability and explosive power can be provided.

  本发明揭示了一种具有式I的1-甘氨基-3,3-二硝基环氧乙烷(GDNAZ)，其中将高能量基团二硝基环氧乙烷基团作为爆炸基团的单体中，以及其方法。通过在合成高性能不敏感炸药的能量粘合剂中使用本发明的GDNAZ，可以提供具有增强热稳定性和储存稳定性以及爆炸能力的能量粘合剂。
• [EN] ORGANONITRO THIOETHER COMPOUNDS AND MEDICAL USES THEREOF<br/>[FR] COMPOSÉS D'ORGANONITRO THIOÉTHER ET UTILISATIONS MÉDICALES DE CEUX-CI
  申请人：RADIORX INC

  公开号：WO2013052164A1

  公开（公告）日：2013-04-11

  The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-l-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.

  本发明提供有机硝基硫醚化合物、含有该类化合物的组合物、分离的有机硝基硫醚化合物以及使用该类化合物和组合物治疗患者癌症的方法。本文所述的示例有机硝基硫醚化合物包括2-(3,3-二硝基氮杂环丙烷-1-基)-2-氧代乙基硫醚及其变体。本发明的另一个方面提供了一种制药组合物，包括一种药学上可接受的载体和本文所述的有机硝基硫醚化合物，例如公式I或II的化合物。本发明的另一个方面提供了一种治疗患者癌症的方法。该方法包括向需要治疗癌症的患者投予本文所述的有机硝基硫醚化合物的治疗有效量，例如公式I或II的化合物，以治疗癌症。
• ORGANONITRO THIOETHER COMPOUNDS AND MEDICAL USES THEREOF
  申请人：Scicinski Jan

  公开号：US20140349988A1

  公开（公告）日：2014-11-27

  The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.

  本发明提供了有机硝基硫醚化合物，含有这种化合物的组合物，分离的有机硝基硫醚化合物以及使用这种化合物和组合物治疗患者的方法。本文描述的示例有机硝基硫醚化合物包括2-（3,3-二硝基氮杂环丙烷-1-基）-2-氧乙基硫醚及其变体。本发明的另一个方面提供了一种制药组合物，包括一种药学上可接受的载体和本文所述的有机硝基硫醚化合物，例如式I或II的化合物。本发明的另一个方面提供了一种治疗患者癌症的方法。该方法包括向需要治疗癌症的患者施用本文所述的有机硝基硫醚化合物的治疗有效量，例如式I或II的化合物，以治疗癌症。
• Organonitro Compounds for Use in Treating Non-Hodgkin's Lymphoma and Leukemia, and Methods Relating Thereto
  申请人：Oronsky Bryan T.

  公开号：US20120149678A1

  公开（公告）日：2012-06-14

  The invention provides organonitro compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat non-Hodgkin's lymphoma and certain leukemias in a patient. The compounds, compositions, kits, and methods are contemplated to provide a therapeutic benefit in treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, and acute lymphoblastic leukemia. Exemplary organonitro compounds described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
• METHODS AND COMPOSITIONS COMPRISING A NITRITE-REDUCTASE PROMOTER FOR TREATMENT OF MEDICAL DISORDERS AND PRESERVATION OF BLOOD PRODUCTS
  申请人：RadioRx, Inc.

  公开号：US20140308260A1

  公开（公告）日：2014-10-16

  The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.