2-(phenoxymethyl)-4,5,6,7-tetrahydro-8H-cyclopenta[d][1,2,4]triazolo[1,5-a]pyrimidin-8-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: 2-(phenoxymethyl)-4,5,6,7-tetrahydro-8H-cyclopenta[d][1,2,4]triazolo[1,5-a]pyrimidin-8-one
• 英文别名: 11-(phenoxymethyl)-1,8,10,12-tetrazatricyclo[7.3.0.03,7]dodeca-3(7),8,10-trien-2-one
• 化学式: C₁₅H₁₄N₄O₂
• 分子量: 282.3
• InChiKey: NTJTUCMXXRLUAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  66.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] INHIBITORS OF CANCER INVASION, ATTACHMENT, AND/OR METASTASIS<br/>[FR] INHIBITEURS DE L'INVASION, DE LA PRISE ET/OU DE LA MÉTASTASE DU CANCER
  申请人：UNIV VIRGINIA COMMONWEALTH

  公开号：WO2018089967A1

  公开（公告）日：2018-05-17

  Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

  本文提供的是与MDA-9/Syntenin（syndecan结合蛋白：SDCBP）的PDZ1结构域结合的组合物，从而抑制MDA-9/Syntenin的活性，以及使用这些组合物的方法等等。本文提供的组合物和方法对于治疗癌症和预防癌症转移特别有用，特别是对于MDA-9/Syntenin表达增加的癌症。
• Inhibitors of cancer invasion, attachment, and/or metastasis
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US11008325B2

  公开（公告）日：2021-05-18

  Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

  本文特别提供了与 MDA-9/Syntenin（辛迪卡结合蛋白：SDCBP）的 PDZ1 结构域结合从而抑制 MDA-9/Syntenin 活性的组合物及其使用方法。本文提供的组合物和方法可用于治疗癌症和预防癌症转移，特别是在 MDA-9/Syntenin 表达增加的癌症中。
• COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION
  申请人：Carlson Heather A.

  公开号：US20110105477A1

  公开（公告）日：2011-05-05

  The present invention relates to HIV protease, and methods for inhibiting the function of HIV protease. In particular, present invention provides compounds that inhibit or block the biological activity of HIVp, thereby causing the replication of the HIV virus to be inhibited or to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS. The compounds and formulations also find use in diagnostic and research settings.
• INHIBITORS OF CANCER INVASION, ATTACHMENT, AND/OR METASTASIS
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US20190263824A1

  公开（公告）日：2019-08-29

  Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.
• [EN] METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER STEM CELLS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR INDUIRE L'APOPTOSE DANS DES CELLULES SOUCHES CANCÉREUSES
  申请人：UNIV VIRGINIA COMMONWEALTH

  公开号：WO2021127305A1

  公开（公告）日：2021-06-24

  Provided herein are pharmaceutical compositions and methods useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression. In embodiments, the method includes administering to the subject a combined effective amount of (a) an agent that inhibits MDA-9, and (b) an anti-cancer agent, wherein the anti-cancer agent is a mitotic inhibitor or a histone deacetylase (HDAC) inhibitor.