2-{[3-Cyano-4-phenyl-6-(thiophen-2-YL)pyridin-2-YL]sulfanyl}-N-(3-acetamidophenyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-{[3-Cyano-4-phenyl-6-(thiophen-2-YL)pyridin-2-YL]sulfanyl}-N-(3-acetamidophenyl)acetamide
• 英文别名: N-(3-acetamidophenyl)-2-(3-cyano-4-phenyl-6-thiophen-2-ylpyridin-2-yl)sulfanylacetamide
• 化学式: C₂₆H₂₀N₄O₂S₂
• mdl: MFCD00473208
• 分子量: 484.602
• InChiKey: CAMIVKYLZJNKEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• DIARYLPYRIDINE ANTI-VIRAL COMPOUNDS
  申请人：Kineta, Inc.

  公开号：EP2977085A1

  公开（公告）日：2016-01-27

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.

  本文披露了用于治疗病毒感染的化合物和相关组合物，包括RNA病毒感染，并且可以调节脊椎动物细胞中的RIG-I途径的化合物，包括可以激活RIG-I途径的化合物。
• Antibacterial fab i inhibitors
  申请人：Moir T. Donald

  公开号：US20070027190A1

  公开（公告）日：2007-02-01

  Disclosed herein are antibacterial compounds that inhibit fabl, a NADH-dependent enoyl [acyl carrier protein] reductase enzyme in the fatty acid biosynthesis pathway. The compounds are represented by structural formulas Ia and Ib: R1 and R2 are independently monocyclic aryl or heteroaryl groups, wherein the groups represented by R1 and R2 are optionally substituted with one or more acyclic substituents; R3 is —H or an optionally substituted C1-C8 aliphatic, C3-C8 cycloaliphatic, aryl, or heteroaryl group. X1 is a bond or a C1-C3 alkylene chain that is optionally substituted with a C1-C4 alkyl or an acidic group. X2 is an aryl, heteroaryl or C3-C8 cycloaliphatic ring, wherein the group represented by X2 is optionally substituted with triazole, tetrazole, and/or one or more acyclic substituents.
• Compositions and Methods Related to Fructosamine-3-Kinase Inhibitors
  申请人：Schwartz Michael

  公开号：US20100297046A1

  公开（公告）日：2010-11-25

  The invention relates to compounds and methods for inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin, by way of fructosamine-3-kinase inhibition, thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.
• Anti-Viral Compounds
  申请人：Iadonato Shawn P.

  公开号：US20130039944A1

  公开（公告）日：2013-02-14

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
• US9301952B2
  申请人：——

  公开号：US9301952B2

  公开（公告）日：2016-04-05