(5Z)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5Z)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one
• 英文别名: (5Z)-5-[[5-(3,4-dichlorophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₄H₇Cl₂NO₂S₂
• 分子量: 356.2
• InChiKey: VRRGUXZKRFEHEL-SDQBBNPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways
  申请人：National Institute of Immunology

  公开号：EP1834642A2

  公开（公告）日：2007-09-19

  The current invention presents enoyl-ACP reductase, an enzyme of the type II fatty acid synthesis pathway as a target for treating human malarias and other infectious diseases. We also present in the current invention, 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents. We provide 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents either alone or in combination with other known antimicrobial and antimalarial agents with or without added adjuvants or diluents or carriers.

  本发明将 II 型脂肪酸合成途径中的一种酶--烯酰-ACP 还原酶作为治疗人类疟疾和其他传染性疾病的靶标。本发明还提出了作为抗菌剂和抗疟药物的 2-硫酮噻唑烷-4-酮。我们提供 2-硫酮噻唑烷-4-酮作为抗菌剂和抗疟药物，可以单独使用，也可以与其他已知的抗菌剂和抗疟药物结合使用，可以添加佐剂或稀释剂或载体，也可以不添加佐剂或稀释剂或载体。
• 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways
  申请人：Surolia Avadhesha

  公开号：US20080051445A1

  公开（公告）日：2008-02-28

  The current invention presents enoyl-ACP reductase, an enzyme of the type II fatty acid synthesis pathway as a target for treating human malarias and other infectious diseases. We also present in the current invention, 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents. We provide 2-thioxothiazolidin-4-ones as antimicrobial and antimalarial agents either alone or in combination with other known antimicrobial and antimalarial agents with or without added adjuvants or diluents or carriers.