8-Nitro-5-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]quinoline

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 8-Nitro-5-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]quinoline
• 化学式: C24H17N5O3S
• 分子量: 455.5
• InChiKey: CAYNCODJBVZVDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Compositions and methods for modulating sirtuin activity
  申请人：Kazantsev Aleksey G.

  公开号：US20080021063A1

  公开（公告）日：2008-01-24

  The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).
• COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY
  申请人：Kazantsev Aleksey G.

  公开号：US20090259044A1

  公开（公告）日：2009-10-15

  The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD).
• SMALL MOLECULE ACTIVATORS OF NRF2 PATHWAY
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US20160101098A1

  公开（公告）日：2016-04-14

  This disclosure relates to compounds that act as activators of the NRF2/KEAP1/ARE pathway. Specifically, the compounds provided herein can act as high affinity reversible bindings for the NRF2 inhibitor, KEAP1. In some cases, NRF2/KEAP1/ARE pathway activation compounds are capable of repressing expression of inflammatory markers and/or reducing levels of TNFa to provide neuroprotective anti-inflammatory effects in the CNS. Such compounds are useful in the treatment of a variety of diseases including Huntington's disease, Parkinson's disease, Alzheimer's disease, inflammation, and cancer.
• US8153803B2
  申请人：——

  公开号：US8153803B2

  公开（公告）日：2012-04-10
• US9737525B2
  申请人：——

  公开号：US9737525B2

  公开（公告）日：2017-08-22