肼氢醌络合物 | 97108-34-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 肼氢醌络合物
• 英文名称: hydrazine hydroquinone complex
• 英文别名: hydrazine-hydroquinone complex；hydroquinone hydrazine (1:1)；hydroquinone; compound with hydrazine；Hydrochinon; Verbindung mit Hydrazin；Benzene-1,4-diol;hydrazine
• CAS: 97108-34-4
• 化学式: C₆H₆O₂*H₄N₂
• 分子量: 142.158
• InChiKey: XTOKBQLTBGASEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.08
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.5
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  肼氢醌络合物 、 对羟基苯甲醛 反应 1.0h， 以98%的产率得到bis(4-hydroxybenzylidene)hydrazine
  参考文献：
  名称：

  Solid-state reactivity of the hydrazine-hydroquinone complex

  摘要：

  The solid-state reactivities of the hydrazine-hydroquinone 1:1 complex and of hydrazine hydrochloride with solid aldehydes, ketones, carboxylic acids, thiohydantoin and 4-nitrophenyl isothiocyanate were investigated. Only the hydrazine complex provides quantitative additions, condensations, ring openings and ring closures. The solid-state mechanisms were investigated by atomic force microscopy (AFM) and the Ear-reaching anisotropic molecular movements are correlated with the crystal packing, both on the hydrazine complex surface and on the surface of two benzaldehydes. The hydrazine moves into the aldehyde crystals for chemical reaction without melting. Characteristic surface features are created by the common phase rebuilding and phase transformation on both the hydrazine-donating and -accepting crystals. Copyright (C) 2000 John Wiley & Sons, Ltd. Additional material for this paper is available from the epoc website at http://www.wiley.com/epoc.

  DOI：

  10.1002/1099-1395(200007)13:7<388::aid-poc278>3.0.co;2-h
• 作为产物：
  描述：

  对苯二酚 在 一水合肼 作用下， 以94.7%的产率得到肼氢醌络合物
  参考文献：
  名称：

  Isolation of anhydrous hydrazine as stable inclusion complexes with hydroquinone and p-methoxyphenol, and their solid state reaction with esters which gives pure hydrazides

  摘要：

  无水肼在纯净状态下与对苯二酚或对甲氧基苯酚分离成稳定的包合物晶体，其 X 射线结构已被分析；肼包合物与酯的固态反应生成的肼几乎不含酸性肼盐副产物。

  DOI：

  10.1039/c39950001531
• 作为试剂：
  描述：

  2-硫代乙内酰脲 在 肼氢醌络合物 作用下， 反应 1.0h， 以100%的产率得到thiohydantoic acid hydrazide
  参考文献：
  名称：

  Solid-state reactivity of the hydrazine-hydroquinone complex

  摘要：

  The solid-state reactivities of the hydrazine-hydroquinone 1:1 complex and of hydrazine hydrochloride with solid aldehydes, ketones, carboxylic acids, thiohydantoin and 4-nitrophenyl isothiocyanate were investigated. Only the hydrazine complex provides quantitative additions, condensations, ring openings and ring closures. The solid-state mechanisms were investigated by atomic force microscopy (AFM) and the Ear-reaching anisotropic molecular movements are correlated with the crystal packing, both on the hydrazine complex surface and on the surface of two benzaldehydes. The hydrazine moves into the aldehyde crystals for chemical reaction without melting. Characteristic surface features are created by the common phase rebuilding and phase transformation on both the hydrazine-donating and -accepting crystals. Copyright (C) 2000 John Wiley & Sons, Ltd. Additional material for this paper is available from the epoc website at http://www.wiley.com/epoc.

  DOI：

  10.1002/1099-1395(200007)13:7<388::aid-poc278>3.0.co;2-h

文献信息

• S6K1 PROTEIN KINASE INHIBITORS AS CANCER THERAPEUTICS
  申请人：Xavier University of Louisiana

  公开号：US20210323919A1

  公开（公告）日：2021-10-21

  The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer.

  本公开涉及作为蛋白激酶抑制剂的化合物，特别是RPS6K1以及其合成。此外，本公开教导了利用这些化合物治疗增殖性疾病，包括癌症，特别是乳腺癌，尤其是ER+和/或HER2+乳腺癌，前列腺癌，肺癌和转移性癌症。
• Hydrazine-Hydroquinone Complex as an Efficient Solid Phase Hydrazine Donor: High Yield Synthesis of Luminol and Isoluminol
  作者：Gautam Chattopadhyay、Partha Sinha Ray

  DOI：10.3184/174751911x13058077114827

  日期：2011.6

  Isomeric aminophthalhydrazides, luminol and isoluminol were easily obtained from the corresponding aminophthalimides by solid phase hydrazinolysis with the hydrazine–-hydroquinone complex in high yields. Synthesis of a novel chemiluminescent agent, a heterocyclic analogue of isoluminol related to aminoimidazolecarboxamide, is also described.

  氨基邻苯二甲酰肼异构体、鲁米诺和异鲁米诺很容易从相应的氨基邻苯二甲酰亚胺通过固相肼解与肼 - 对苯二酚络合物以高产率获得。还描述了一种新型化学发光剂（与氨基咪唑甲酰胺相关的异鲁米诺的杂环类似物）的合成。
• Use of a hydroquinone compound with hydrazine (1:1 molar ratio) as an
  申请人：Olin Corporation

  公开号：US04512909A1

  公开（公告）日：1985-04-23

  Disclosed is an improved oxygen-scavenging and corrosion-inhibiting agent for fluidic systems comprising a hydroquinone compound with hydrazine (1:1 molar ratio). Also disclosed are methods for using this agent.

  本发明涉及一种改进的氧气吞噬和抑制液体系统腐蚀的剂，其包括一个羟基苯醌化合物和肼（1:1摩尔比）。同时，本发明还涉及使用该剂的方法。
• Methods and systems for hydrazine remediation
  申请人：——

  公开号：US20040024251A1

  公开（公告）日：2004-02-05

  Methods of and systems for remediating hydrazine spills, solutions and hydrazine-contaminated objects including areas thereof. Initially, an aqueous solution comprising a dicarbonyl-compound can be prepared. The aqueous solution can then be provided for application to an object contaminated with a hydrazine group compound. The hydrazine group compounds are converted to a stable organic compound as a result of a reaction of the dicarbonyl-compound and hydrazine group compound. Conversion assists in the remediation of the hydrazine group compound from the object. The stable organic compound produced as a result of the reaction between the dicarbonyl-compound and hydrazine group compound can then be treated with a metal catalyst and hydrogen to produce glutamine or a derivative thereof. Both the stable organic compound and glutamine can undergo microbiological degradation without further remedial intervention.

  治理肼泄漏、溶液和受肼污染的物体及其区域的方法和系统。首先，可以准备含有二羰基化合物的水溶液。然后，可以将水溶液提供给受肼族化合物污染的物体进行应用。由于二羰基化合物和肼族化合物的反应，肼族化合物被转化为稳定的有机化合物。转化有助于从物体中治理肼族化合物。由二羰基化合物和肼族化合物反应产生的稳定有机化合物可以经过金属催化剂和氢处理，以产生谷氨酰胺或其衍生物。稳定有机化合物和谷氨酰胺都可以经过微生物降解而不需要进一步的治理干预。
• Curtius; Thun, Journal fur praktische Chemie (Leipzig 1954), 1891, vol. <2> 44, p. 176
  作者：Curtius、Thun

  DOI：——

  日期：——