(Z)-3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid | 2055732-24-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid
• 英文别名: BI-MFM3；Claficapavir；3-[(5Z)-5-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
• CAS: 2055732-24-4
• 化学式: C₁₇H₁₂ClNO₄S₂
• 分子量: 393.872
• InChiKey: YZLFZFALAZYTCI-ZROIWOOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (Z)-3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid 在 sodium hydroxide 作用下， 以 水 为溶剂， 以86%的产率得到(Z)-3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid sodium salt
  参考文献：
  名称：

  KR2018/130895

  摘要：

  公开号：

文献信息

• NOVEL RHODANINE DERIVATIVES, METHOD FOR PREPARING SAME, AND PAHRMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF AIDS CONTAINING THE RHODANINE DERIVATIVES AS ACTIVE INGREDIENTS
  申请人：You Ji Chang

  公开号：US20130096125A1

  公开（公告）日：2013-04-18

  Disclosed are novel rhodanine derivatives which are inhibitory of HIV activity. Also provided are a method for preparing the novel rhodanine derivatives, and a pharmaceutical composition for the prevention or treatment of AIDS containing the rhodanine derivatives as active ingredients. Having high inhibitory activity against HIV, the rhodanine derivatives can be effectively used in the prophylaxis or therapy of AIDS.

  揭示了一种新颖的罗丹宁衍生物，对HIV活性具有抑制作用。还提供了一种制备这种新颖罗丹宁衍生物的方法，以及一种包含罗丹宁衍生物作为活性成分的用于预防或治疗艾滋病的药物组合物。罗丹宁衍生物对HIV具有高抑制活性，可以有效用于艾滋病的预防或治疗。
• Pharmaceutical composition for preventing or treating AIDS comprising rhodanine derivative
  申请人：AVIXGEN INC.

  公开号：US10821101B2

  公开（公告）日：2020-11-03

  The present invention relates to a pharmaceutical composition for preventing or treating AIDS, comprising a rhodanine derivative and a nucleoside reverse transcriptase inhibitor. A complex composition of the present invention exhibits a synergistic effect in terms of anti-HIV activity as compared with a case where each of the compounds is used as a single drug. Thus, the composition provides sufficient anti-HIV activity and exhibits an excellent effect of decreasing side effects such as toxicity even in a case where each compound is administered in a small amount. Accordingly, the present invention is expected to greatly contribute to treatment of AIDS patients.

  本发明涉及一种用于预防或治疗艾滋病的药物组合物，其中包括一种罗丹宁衍生物和一种核苷类逆转录酶抑制剂。与将每种化合物作为单一药物使用的情况相比，本发明的复方组合物在抗艾滋病毒活性方面表现出协同效应。因此，本发明的复方组合物具有足够的抗 HIV 活性，即使在每种化合物的用量较小的情况下，也能很好地降低副作用（如毒性）。因此，本发明有望极大地促进艾滋病患者的治疗。
• Pharmaceutical composition for preventing or treating aids comprising rhodanine derivative
  申请人：AVIXGEN INC.

  公开号：US11141407B2

  公开（公告）日：2021-10-12

  The present invention relates to a pharmaceutical composition for preventing or treating AIDS, comprising a rhodanine derivative and a nucleoside reverse transcriptase inhibitor. A complex composition of the present invention exhibits a synergistic effect in terms of anti-HIV activity as compared with a case where each of the compounds is used as a single drug. Thus, the composition provides sufficient anti-HIV activity and exhibits an excellent effect of decreasing side effects such as toxicity even in a case where each compound is administered in a small amount. Accordingly, the present invention is expected to greatly contribute to treatment of AIDS patients.

  本发明涉及一种用于预防或治疗艾滋病的药物组合物，其中包括一种罗丹宁衍生物和一种核苷类逆转录酶抑制剂。与将每种化合物作为单一药物使用的情况相比，本发明的复方组合物在抗艾滋病毒活性方面表现出协同效应。因此，本发明的复方组合物具有足够的抗 HIV 活性，即使在每种化合物的用量较小的情况下，也能很好地降低副作用（如毒性）。因此，本发明有望极大地促进艾滋病患者的治疗。
• Inhibition of lethal factor protease activity from anthrax toxin
  申请人：Pellecchia Maurizio

  公开号：US20080033025A1

  公开（公告）日：2008-02-07

  The present invention provides compounds that efficiently and specifically inhibit lethal factor (LF) protease activity of anthrax toxin.
• PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AIDS COMPRISING RHODANINE DERIVATIVE
  申请人：AVIXGEN INC.

  公开号：US20210000802A1

  公开（公告）日：2021-01-07

  The present invention relates to a pharmaceutical composition for preventing or treating AIDS, comprising a rhodanine derivative and a nucleoside reverse transcriptase inhibitor. A complex composition of the present invention exhibits a synergistic effect in terms of anti-HIV activity as compared with a case where each of the compounds is used as a single drug. Thus, the composition provides sufficient anti-HIV activity and exhibits an excellent effect of decreasing side effects such as toxicity even in a case where each compound is administered in a small amount. Accordingly, the present invention is expected to greatly contribute to treatment of AIDS patients.