CCG4986 | 7134-19-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: CCG4986
• 英文别名: methyl N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate；4-Nitro-N-(4-chlor-benzolsulfonyl)-benzolsulfinsaeure-imid-methylester；Unii-TJ1W0H78EJ；(NZ)-4-chloro-N-[methoxy-(4-nitrophenyl)-λ4-sulfanylidene]benzenesulfonamide
• CAS: 7134-19-2
• 化学式: C₁₃H₁₁ClN₂O₅S₂
• 分子量: 374.826
• InChiKey: GIFNUYPIOIDEGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  129
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] NEURABIN SCAFFOLDING OF THE ADENOSINE RECEPTOR AND RGS4 REGULATES ANTI-SEIZURE EFFECT OF ENDOGENOUS ADENOSINE<br/>[FR] ECHAFAUDAGE DE LA NEURABINE DU RÉCEPTEUR DE L'ADÉNOSINE ET RGS4 RÈGLANT L'EFFET ANTI-CRISE DE L'ADÉNOSINE ENDOGÈNE
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2013049026A2

  公开（公告）日：2013-04-04

  The disclosure encompasses methods of providing a therapeutic method of reducing the effects in an animal or human of neural damage, in particular, but not only, neural damage induced by the onset of a seizure. It has been surprisingly found that neural protection resulting from endogenous adenosine interactions with the adenosine receptor sub-type may be effectively enhanced by preventing the RGS4 protein from inhibiting cell signaling pathways activated through ligand binding to the A1 R receptor. It has been found that antagonists of the RGS4 protein or disruption in the availability of the scaffold protein neurabin allow endogenous adenosine to activate the A1 R found on neural cells and thereby provide targeted protection to these cell types.