N-[6-(dimethoxymethyl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide | 1031890-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: N-[6-(dimethoxymethyl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide
• CAS: 1031890-81-9
• 化学式: C₁₄H₁₉N₅O₄
• 分子量: 321.336
• InChiKey: VMWQRZRFLWSKFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-[6-(dimethoxymethyl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以76%的产率得到2-Pivaloylamino-6-formylpteridin-4-one
  参考文献：
  名称：

  Pterin-based highly selective, ratiometric, and sensitive ‘naked-eye’ sensor for acetate

  摘要：

  The design and synthesis of a new pterin-based ratiometric and sensitive 'naked-eye' sensor R for highly selective recognition of acetate are reported. The acidic lactam NH and the NH of 2-N-pivaloyl group of receptor R along with 2,4-dinitrophenyl hydrazone group having the other acidic NH moiety lead to the binding of acetate anion in a 1:2 ratio by change of spectroscopic behavior on complexation (UV-vis and H-1 NMR studies) which is also proven by job plot. The sharp color change from light yellow to violet promises R to be a useful chromogenic ratiometric sensor for acetate amongst other common anions. (C) 2014 Elsevier Ltd. All rights reserved,

  DOI：

  10.1016/j.tetlet.2014.03.068
• 作为产物：
  描述：

  3,3-dimethoxy-2-oxo-propanal 在 4-二甲氨基吡啶 、 sodium sulfite 作用下， 以 水 为溶剂， 生成 N-[6-(dimethoxymethyl)-4-oxo-3H-pteridin-2-yl]-2,2-dimethylpropanamide
  参考文献：
  名称：

  Pterin-based highly selective, ratiometric, and sensitive ‘naked-eye’ sensor for acetate

  摘要：

  The design and synthesis of a new pterin-based ratiometric and sensitive 'naked-eye' sensor R for highly selective recognition of acetate are reported. The acidic lactam NH and the NH of 2-N-pivaloyl group of receptor R along with 2,4-dinitrophenyl hydrazone group having the other acidic NH moiety lead to the binding of acetate anion in a 1:2 ratio by change of spectroscopic behavior on complexation (UV-vis and H-1 NMR studies) which is also proven by job plot. The sharp color change from light yellow to violet promises R to be a useful chromogenic ratiometric sensor for acetate amongst other common anions. (C) 2014 Elsevier Ltd. All rights reserved,

  DOI：

  10.1016/j.tetlet.2014.03.068

文献信息

• Molybdenum pentachloride (MoCl5) or molybdenum dichloride dioxide (MoO2Cl2): advanced catalysts for thioacetalization of heterocyclic, aromatic and aliphatic compounds
  作者：Shyamaprosad Goswami、Annada C. Maity

  DOI：10.1016/j.tetlet.2008.03.048

  日期：2008.5

  A new, convenient and mild method for thioacetalization of heterocyclic, aromatic and aliphatic compounds catalyzed by MoCl(5) or MoO(2)Cl(2) is described. This novel method is important for the synthesis of the difficult to prepare heterocyclic thioacetals such as the pterin thioacetals and it offers significant advantages such as high conversion, short reaction times and simplicity in operation. (C) 2008 Elsevier Ltd. All rights reserved.