2-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]benzamide
• 化学式: C₁₄H₈BrClF₃NO
• 分子量: 378.57
• InChiKey: VMXYHCZQLOBACI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF<br/>[FR] ACTIVATEURS D'HISTONE ACÉTYLTRANSFÉRASE ET COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：UNIV COLUMBIA

  公开号：WO2018017858A1

  公开（公告）日：2018-01-25

  The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

  这项发明提供了治疗癌症、神经退行性疾病、与淀粉样蛋白β沉积、Tau蛋白水平和/或α-突触核蛋白积累相关的疾病状态的制药组合物和方法，通过向受试者投予HAT调节剂和HDAC调节剂。
• [EN] HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF<br/>[FR] ACTIVATEURS D'HISTONE ACÉTYLTRANSFÉRASE ET UTILISATION DESDITS ACTIVATEURS
  申请人：UNIV COLUMBIA

  公开号：WO2015153410A1

  公开（公告）日：2015-10-08

  The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

  这项发明提供了包含调节组蛋白乙酰转移酶（HAT）的化合物和化合物组合物。该发明还提供了一种通过向受试者投药调节HAT的化合物来治疗神经退行性疾病、与淀粉样蛋白β沉积、Tau蛋白水平以及α-突触核蛋白积累有关的疾病，以及癌症的方法。
• HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20170182054A1

  公开（公告）日：2017-06-29

  The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
• HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20180021273A1

  公开（公告）日：2018-01-25

  The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.