1-(4-Bromobenzyl)-4-cyclohexylpiperazine | 423745-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Bromobenzyl)-4-cyclohexylpiperazine
• 英文别名: 1-[(4-bromophenyl)methyl]-4-cyclohexylpiperazine
• CAS: 423745-68-0
• 化学式: C₁₇H₂₅BrN₂
• 分子量: 337.303
• InChiKey: BLJIAGGVJUXNOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS<br/>[FR] COMPOSÉS UTILISABLES POUR LE TRAITEMENT DE TROUBLES INFLAMMATOIRES
  申请人：SCHERING CORP

  公开号：WO2010054279A1

  公开（公告）日：2010-05-14

  This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

  本发明涉及式(I)的化合物：（化学式应按照纸质摘要中的形式插入在此处）（I）或其药用可接受的盐、溶剂合物或异构体，可用于治疗由MMPs、ADAMs、TACE、聚集素酶、TNF-或其组合介导的疾病或症状。
• COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
  申请人：Kozlowski Joseph A.

  公开号：US20120010181A1

  公开（公告）日：2012-01-12

  This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
• US8541572B2
  申请人：——

  公开号：US8541572B2

  公开（公告）日：2013-09-24
• [EN] COMPOUNDS AND METHODS OF PROMOTING OLIGODENDROCYTE PRECURSOR DIFFERENTIATION<br/>[FR] COMPOSÉS ET PROCÉDÉS FAVORISANT LA DIFFÉRENCIATION DE PRÉCURSEURS D'OLIGODENDROCYTES
  申请人：CLEVELAND CLINIC FOUND

  公开号：WO2022006518A1

  公开（公告）日：2022-01-06

  A method of promoting the differentiation of an oligodendrocyte precursor cell is disclosed herein. The method includes administering to the oligodendrocyte precursor cell an effective amount of a compound capable of promoting oligodendrocyte precursor cell differentiation. Also disclosed herein is a method of treating a neurodegenerative disorder, including a demyelinating disease such as multiple sclerosis, in a subject in need thereof, comprising administering to the subject a compound disclosed herein.