acetic acid-(5α-androst-16-en-3α-yl ester) | 95118-94-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: acetic acid-(5α-androst-16-en-3α-yl ester)
• 英文别名: Essigsaeure-(5α-androst-16-en-3α-ylester)；[(3R,5S,8R,9S,10S,13R,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• CAS: 95118-94-8
• 化学式: C₂₁H₃₂O₂
• 分子量: 316.484
• InChiKey: MUSSUDIZUKJZHB-TVWVXWENSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (3α,5α)-16-烯-3-甾醇 、 乙酸酐 在 吡啶 作用下， 生成 acetic acid-(5α-androst-16-en-3α-yl ester)
  参考文献：
  名称：

  Mason; Schneider, Journal of Biological Chemistry, 1950, vol. 184, p. 593,597

  摘要：

  DOI：

文献信息

• Car modulators: screening and treatment of hypercholesterolemia
  申请人：——

  公开号：US20020152479A1

  公开（公告）日：2002-10-17

  This invention provides methods that are useful for identifying therapeutic agents for the treatment of a CAR-mediated disorder or condition. The methods include determining whether the candidate therapeutic agent can: interact directly with CAR, modulate CAR-mediated gene expression, decrease CAR antagonist elevation of a cholesterol indicator in a mammal, or decrease a cholesterol level indicator in a mammal with a defective CAR. Also provided are CAR agonists.

  本发明提供的方法可用于确定治疗CAR介导的疾病或病症的治疗剂。这些方法包括确定候选治疗剂是否能：与 CAR 直接相互作用、调节 CAR 介导的基因表达、降低哺乳动物体内胆固醇指标的 CAR 拮抗剂升高，或降低有缺陷 CAR 的哺乳动物体内的胆固醇水平指标。还提供了 CAR 激动剂。
• [EN] CAR MODULATORS: SCREENING AND TREATMENT OF HYPERCHOLESTEROLEMIA<br/>[FR] MODULATEURS DE CAR : CRIBLAGE ET TRAITEMENT DE L'HYPERCHOLESTEROLEMIE
  申请人：TULARIK INC

  公开号：WO2001051045A2

  公开（公告）日：2001-07-19

  This invention provides methods that are useful for identifying therapeutic agents for the treatment of a CAR-mediated disorder or condition. The methods include determining whether the candidate therapeutic agent can: interact directly with CAR, modulate CAR-mediated gene expression, decrease CAR antagonist elevation of a cholesterol indicator in a mammal, or decrease a cholesterol level indicator in a mammal with a defective CAR. Also provided are CAR agonists.____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________