Methyl 2-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate
• 英文别名: methyl 2-[5-[(E)-(3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate
• 化学式: C₂₃H₁₇NO₄S₂
• 分子量: 435.5
• InChiKey: DSLGGWUUDXOOTH-DEDYPNTBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Use of Thiazolidinone Derivatives as Antiangiogenic Agents
  申请人：Cassin Mara

  公开号：US20080261980A1

  公开（公告）日：2008-10-23

  The invention relates to the use of compounds of general formula (I), in which R 1 , R 2 and X are as defined in the description for the preparation of pharmaceutical compositions for the treatment of pathologies in which inhibition of the interaction between HIF-1α and p300 is beneficial, in particular as antiangiogenic medicaments for the therapy of solid tumors.

  本发明涉及使用通式(I)中的化合物，其中R1、R2和X如说明书中所定义，用于制备药物组合物，用于治疗抑制HIF-1α和p300之间相互作用有益的病理情况，特别是作为治疗实体瘤的抗血管生成药物。
• USE OF THIAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF SOLID TUMORS
  申请人：Cell Therapeutics Europe S.R.L.

  公开号：EP1830848B1

  公开（公告）日：2009-12-16
• MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES
  申请人：Dariavach Piona

  公开号：US20110112098A1

  公开（公告）日：2011-05-12

  The present invention relates to the C-13 molecule (methyl 2-5-[(3-benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}-benzoate) and to organic molecules functionally equivalent to the C-13 molecule, capable of inhibiting the binding of an antibody or antibody fragment with the human Syk protein tyrosine kinase, to the use of these molecules for the production of medicaments for the prevention or treatment of diseases dependent on metabolic pathways involving Syk, and also to a method for identifying such molecules.
• US9504676B2
  申请人：——

  公开号：US9504676B2

  公开（公告）日：2016-11-29