[(Z)-1-(4-methylphenyl)ethylideneamino]thiourea | 7410-54-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(Z)-1-(4-methylphenyl)ethylideneamino]thiourea
• CAS: 7410-54-0
• 化学式: C₁₀H₁₃N₃S
• 分子量: 207.3
• InChiKey: CLXMWTWYQLEKAI-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] METHOD OF SUPPRESSING CANCER BY RNA m6A METHYLTRANSFERASE METTL16 INHIBITORS<br/>[FR] PROCÉDÉ DE SUPPRESSION DU CANCER PAR DES INHIBITEURS D'ARN M6A MÉTHYLTRANSFÉRASE METTL16
  申请人：CHEMESTMED LTD

  公开号：WO2021116477A1

  公开（公告）日：2021-06-17

  The present invention relates generally to compositions and methods for treating cancer. Provided herein are compounds are reported that specifically modulate RNA methylation by inhibition of the RNA methyltransferase METTL16. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as glioblastoma, astrocytoma, acute myeloid leukemia, acute monocytic leukemia, chronic myelogenous leukemia, T acute lymphoblastic leukemia and the like.