3-[4-[3-(Hydroxymethyl)phenyl]phenyl]propanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[4-[3-(Hydroxymethyl)phenyl]phenyl]propanoic acid
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.3
• InChiKey: DAVYRJHIKJVVIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
  申请人：Ulven Trond

  公开号：US20110152315A1

  公开（公告）日：2011-06-23

  There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type I1 diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.

  提供了一种新的化合物，能够调节G蛋白偶联受体GPR40，包括该化合物的组合物以及使用它们的方法，用于控制体内胰岛素水平和治疗诸如2型糖尿病、高血压、酮症酸中毒、肥胖症、葡萄糖耐受性不良以及与异常高或低血浆脂蛋白、甘油三酯或葡萄糖水平有关的相关疾病。
• 3'END CAPS FOR RNA-INTERFERRING AGENTS FOR USE IN RNA
  申请人：Novartis AG

  公开号：EP3722277A2

  公开（公告）日：2020-10-14

  The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

  本公开涉及新型化合物和包含 RNAi 剂的组合物，该 RNAi 剂包含作为 3' 端帽的新型化合物。本发明还涉及制造此类组合物的工艺，以及此类组合物的方法和用途，例如介导 RNA 干扰。
• 3′end caps for RNAi agents for use in RNA interference
  申请人：Novartis AG

  公开号：US10227588B2

  公开（公告）日：2019-03-12

  The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3′ end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

  本公开涉及新型化合物和组合物，该组合物包含作为 3′端盖的新型化合物的 RNAi 剂。本发明还涉及制造这种组合物的工艺，以及这种组合物的方法和用途，如介导 RNA 干扰。
• 3′ end caps for RNAi agents for use in RNA interference
  申请人：Novartis AG

  公开号：US11008570B2

  公开（公告）日：2021-05-18

  The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3′ end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

  本公开涉及新型化合物和组合物，该组合物包含作为 3′端盖的新型化合物的 RNAi 剂。本发明还涉及制造这种组合物的工艺，以及这种组合物的方法和用途，如介导 RNA 干扰。
• 3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE
  申请人：BARYZA Jeremy Lee

  公开号：US20160304863A1

  公开（公告）日：2016-10-20

  The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3′ end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.