N-(3-(3,5-dimethoxy-phenylamino)quinoxalin-2-yl)-4-methylbenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-(3,5-dimethoxy-phenylamino)quinoxalin-2-yl)-4-methylbenzenesulfonamide
• 英文别名: N-[3-(3,5-dimethoxyanilino)quinoxalin-2-yl]-4-methylbenzenesulfonamide
• 化学式: C₂₃H₂₂N₄O₄S
• 分子量: 450.518
• InChiKey: BWLPXMKWMRGOKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Pyrazine Derivatives and Use as P13k Inhibitors
  申请人：Gaillard Pascale

  公开号：US20090082356A1

  公开（公告）日：2009-03-26

  The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

  本发明涉及式（I）的吡嗪衍生物，特别用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植、移植排斥或肺部损伤。
• Methods of Using PI3K and MEK Modulators
  申请人：Aftab Dana T.

  公开号：US20100075947A1

  公开（公告）日：2010-03-25

  The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.

  本发明提供了一种使用抑制激酶的化合物组合来治疗癌症的方法，更具体地说是抑制MEK和PI3K的化合物组合。
• Phosphatidylinositol 3-Kinase Inhibitors and Methods of Their Use
  申请人：Bajjalieh William

  公开号：US20100087440A1

  公开（公告）日：2010-04-08

  The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.

  本发明涉及磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂，该酶与多种恶性肿瘤相关，如卵巢癌、宫颈癌、乳腺癌、结肠癌、直肠癌和胶质母细胞瘤等。因此，本发明的化合物可用于治疗、预防和/或抑制这些疾病。
• Phosphatidylinositol 3-Kinase Inhibitors And Methods Of Their Use
  申请人：Bajjalieh William

  公开号：US20110207712A1

  公开（公告）日：2011-08-25

  The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.

  本发明涉及磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂，PI3K与多种恶性肿瘤相关，如卵巢癌、宫颈癌、乳腺癌、结肠癌、直肠癌和胶质母细胞瘤等。因此，本发明化合物可用于治疗、预防和/或抑制这些疾病。
• PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS
  申请人：Gaillard Pascale

  公开号：US20110312960A1

  公开（公告）日：2011-12-22

  The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

  本发明涉及式（I）的吡嗪衍生物，特别是用于治疗和/或预防自身免疫性疾病和/或炎症性疾病、心血管疾病、神经退行性疾病、细菌或病毒感染、肾脏疾病、血小板聚集、癌症、移植、移植排斥或肺损伤。