[2-(9H-fluoren-9-yl)ethyl](methyl)amine | 1145661-12-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: [2-(9H-fluoren-9-yl)ethyl](methyl)amine
• 英文别名: 2-(9H-fluoren-9-yl)-N-methylethanamine
• CAS: 1145661-12-6
• 化学式: C₁₆H₁₇N
• 分子量: 223.318
• InChiKey: DAGFFENGDRSMIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.41
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.03
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  [2-(9H-fluoren-9-yl)ethyl](methyl)amine 、 1-[4-(3,4-Difluorophenyl)piperazin-1-yl]prop-2-en-1-one 在 sodium hydroxide 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 20.0h， 生成 3-((2-(9H-fluoren-9-yl)ethyl)(methyl)amino)-1-(4-(3,4-difluorophenyl)piperazin-1-yl)propan-1-one hydrochloride
  参考文献：
  名称：

  Discovery of novel non-peptidic β-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists

  摘要：

  Structural simplification of the core moieties of obeline and ergoline somatostatin sst(1) receptor antagonists, followed by systematic optimization, led to the identification of novel, highly potent and selective sst(1) receptor antagonists. These achiral, non-peptidic compounds are easily prepared and show promising PK properties in rodents. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.072
• 作为产物：
  描述：

  N-methyl-9-fluoreneacetamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 4.0h， 以50%的产率得到[2-(9H-fluoren-9-yl)ethyl](methyl)amine
  参考文献：
  名称：

  Discovery of novel non-peptidic β-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists

  摘要：

  Structural simplification of the core moieties of obeline and ergoline somatostatin sst(1) receptor antagonists, followed by systematic optimization, led to the identification of novel, highly potent and selective sst(1) receptor antagonists. These achiral, non-peptidic compounds are easily prepared and show promising PK properties in rodents. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.072

文献信息

• SILOXANE BASED POLYMERIC LIQUID MATERIAL AND METHOD FOR PREPARING THE SAME
  申请人：EMPA Eidgenössische Materialprüfungs- und Forschungsanstalt

  公开号：EP3835338A1

  公开（公告）日：2021-06-16

  A new class of liquid polysiloxane materials obtainable from cost-effective commodity precursors allow tailoring a plurality of (multi)-functional properties. The materials are classified in terms of their chemical identity, which comprises Q-type non-organofunctional, T-type monoorganofunctional and optional D-type diorganofunctional moieties. The T-type organofunctional species within a polymeric MBB can be present in various preferred combinations defined by spatial, stereochemical and compositional factors. The corresponding method of production for the liquid polymeric polysiloxanes involves a scalable, non-hydrolytic acetic anhydride method either in a simple one-step format to create statistically distributed "core-only" hyperbranched poly-alkoxysiloxanes or as a two- or multistep process to create "core-shell" materials.

  一类新型液态聚硅氧烷材料可从具有成本效益的商品前体中获得，可定制多种（多功能）特性。这些材料按其化学特性分类，包括 Q 型非有机官能团、T 型单有机官能团和可选的 D 型二有机官能团。聚合物 MBB 中的 T 型有机官能团可以通过空间、立体化学和组成因素确定的各种优选组合出现。液态聚合聚硅氧烷的相应生产方法包括一种可扩展的非水解醋酸酐方法，该方法可以是简单的一步法，用于生产统计分布的 "纯核 "超支化聚烷氧基硅氧烷；也可以是两步法或多步法，用于生产 "核壳 "材料。
• Discovery of novel non-peptidic β-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists
  作者：Thomas Troxler、Konstanze Hurth、Henri Mattes、Mahavir Prashad、Philippe Schoeffter、Daniel Langenegger、Albert Enz、Daniel Hoyer

  DOI：10.1016/j.bmcl.2009.01.072

  日期：2009.3

  Structural simplification of the core moieties of obeline and ergoline somatostatin sst(1) receptor antagonists, followed by systematic optimization, led to the identification of novel, highly potent and selective sst(1) receptor antagonists. These achiral, non-peptidic compounds are easily prepared and show promising PK properties in rodents. (C) 2009 Elsevier Ltd. All rights reserved.