7-methoxy-4-methyl-2H-chromene | 50585-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-methoxy-4-methyl-2H-chromene
• 英文别名: 7-Methoxy-4-methyl-2H-1-benzopyran
• CAS: 50585-00-7
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: IDRSZYOJAWDVSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-methoxy-4-methyl-2H-chromene 、 2-(Benzyloxy)-1,4-benzoquinone 在 titanium(IV) isopropylate 、 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 9.0h， 以64%的产率得到(6aS,11aS)-9-(苄氧基)-3-甲氧基-11a-甲基-6a,11a-二氢-6H-[1]苯并呋喃并[3,2-c]色烯-8-醇
  参考文献：
  名称：

  Stereoselective syntheses of substituted pterocarpans with anti-HIV activity, and 5-aza-/5-thia-pterocarpan and 2-aryl-2,3-dihydrobenzofuran analogues

  摘要：

  Oxygenated pterocarpans and 5-azapterocarpans are prepared utilizing Lewis acid-promoted reactions of 2-alkoxy-1,4-benzoquinones with 2H-chromenes and N-tosyl-3,2-dihydroquinolines, respectively. Similarly, benzannulated analogues are prepared via reactions of 5-alkoxy-1,4-naphthoquinones with chromenes, and related 2-aryl-2,3-dihydrobenzofurans result from reactions of styrenes with the quinones. Syntheses of 5-thiapterocarpans are also described utilizing Pd(0)-coupling of o-chloromercuriophenols with 2H-chromenes. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0968-0896(96)00192-7
• 作为产物：
  描述：

  4H-1-苯并吡唑-4-酮 在 对甲苯磺酸 作用下， 以 四氢呋喃 、 乙醚 、 苯 为溶剂， 反应 8.0h， 生成 7-methoxy-4-methyl-2H-chromene
  参考文献：
  名称：

  Stereoselective syntheses of substituted pterocarpans with anti-HIV activity, and 5-aza-/5-thia-pterocarpan and 2-aryl-2,3-dihydrobenzofuran analogues

  摘要：

  Oxygenated pterocarpans and 5-azapterocarpans are prepared utilizing Lewis acid-promoted reactions of 2-alkoxy-1,4-benzoquinones with 2H-chromenes and N-tosyl-3,2-dihydroquinolines, respectively. Similarly, benzannulated analogues are prepared via reactions of 5-alkoxy-1,4-naphthoquinones with chromenes, and related 2-aryl-2,3-dihydrobenzofurans result from reactions of styrenes with the quinones. Syntheses of 5-thiapterocarpans are also described utilizing Pd(0)-coupling of o-chloromercuriophenols with 2H-chromenes. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0968-0896(96)00192-7

文献信息

• Facile Construction of the Benzofuran and Chromene Ring Systems via Pd^II-Catalyzed Oxidative Cyclization
  作者：So Won Youn、Jeong Im Eom

  DOI：10.1021/ol051264z

  日期：2005.7.1

  text]. We herein report the development of one-pot procedures for the conversion of allyl aryl ethers to 2-methylbenzofurans (via sequential Claisen rearrangement and oxidative cyclization) and for the conversion of aryl homoallyl ethers to chromenes (via direct oxidative cyclization). It is likely that both reactions proceed via a common Pd-catalyzed pathway involving olefin activation, nucleophilic

  [反应：请参见文字]。我们在本文中报道了一锅法的发展，该方法用于将烯丙基芳基醚转化为2-甲基苯并呋喃（通过顺序的克莱森重排和氧化环化）和用于将芳基高烯丙基醚转化为苯甲基（通过直接氧化环化）。这两种反应都有可能通过常见的Pd催化途径进行，涉及烯烃活化，亲核攻击和β-氢化物消除。
• Tricyclic mono-chromone-2-carboxylic acids
  申请人：Fisons Limited

  公开号：US04159273A1

  公开（公告）日：1979-06-26

  There are described compounds of formula I, ##STR1## in which R.sub.3 represents hydrogen, or alkyl C 1 to 6, R.sub.5 represents hydrogen, hydroxy, alkoxy C 1 to 6, alkanoyloxy C 2 to 6, alkenyloxy C 2 to 6, nitro, -NR.sub.1 R.sub.2, halogen, alkyl C 1 to 6, hydroxy-alkyl C 1 to 6, or hydroxy-alkoxy C 1 to 6, An adjacent pair of X, Y and Z form a --(CH.sub.2).sub.4 --, --CH.dbd.CH--CH.dbd.CH--or --O(CH.sub.2).sub.3 --chain, each of the chains optionally being substituted by one or two C 1 to 6 alkyl groups, and the remaining substituent X or Z represents alkenyl C2 to 6 optionally substituted by phenyl; halogen; or alkyl C 1 to 9 optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy C 1 to 6, Or, when an adjacent pair of X, Y and Z form a chain substituted by one or two C 1 to 6 alkyl groups, the remaining substituent X or Z may be hydrogen, and R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen or alkyl C 1 to 6, And pharmaceutically acceptable derivatives thereof. Processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds are also described.

  本文描述了一种化合物，其化学式为I，其中R.sub.3代表氢或烷基C1至6，R.sub.5代表氢、羟基、烷氧基C1至6、烷酰氧基C2至6、烯酰氧基C2至6、硝基、-NR.sub.1R.sub.2、卤素、烷基C1至6、羟基-烷基C1至6或羟基-烷氧基C1至6。相邻的X、Y和Z形成一个--(CH2)4--、--CH=CH-CH=CH-或--O(CH2)3--链，每个链可选地被一个或两个C1至6烷基取代，剩余的取代基X或Z代表烯基C2至6，可选地被苯基、卤素或烷基C1至9取代，该烷基可选地被一个或多个羟基、卤素、羰基氧、苯基或烷氧基C1至6的基团取代。或者，当相邻的X、Y和Z形成一个被一个或两个C1至6烷基取代的链时，剩余的取代基X或Z可以是氢，R.sub.1和R.sub.2可以相同或不同，分别代表氢或烷基C1至6。还描述了制备该化合物的方法以及含有该化合物的药物，例如抗过敏药物组成物。
• Colonge; Guyot, Bulletin de la Societe Chimique de France, 1958, p. 325,328
  作者：Colonge、Guyot

  DOI：——

  日期：——
• CHATTERJEA J. N.; PRASAD K.; PRASAD R.; SINHA N. D., INDIAN J. CHEM. <IJOC-AP>, 1974, 12, NO 12, 1256-1258
  作者：CHATTERJEA J. N.、 PRASAD K.、 PRASAD R.、 SINHA N. D.

  DOI：——

  日期：——
• US4159273A
  申请人：——

  公开号：US4159273A

  公开（公告）日：1979-06-26