(S)-N-[[ethoxy(phenyl)phosphoryl]-phenylmethyl]-4-methylbenzenesulfinamide | 681460-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-N-[[ethoxy(phenyl)phosphoryl]-phenylmethyl]-4-methylbenzenesulfinamide
• CAS: 681460-73-1
• 化学式: C₂₂H₂₄NO₃PS
• 分子量: 413.477
• InChiKey: POEMHUHLZBRICQ-SUIMDOTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.95
• 重原子数：
  28.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.4
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-N-[[ethoxy(phenyl)phosphoryl]-phenylmethyl]-4-methylbenzenesulfinamide 在 盐酸 作用下， 反应 8.0h， 以52%的产率得到ethyl α-benzylamino-phenylphosphinic acid
  参考文献：
  名称：

  Interesting by-products in the synthesis of chiral α-aminophosphinates from enantiopure sulfinimines

  摘要：

  A new reaction of enantiopure sulfinimines and ethyl phenylphosphinate is given. Several unexpected products were isolated and identified, their mechanism of formation is proposed. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.151
• 作为产物：
  描述：

  (S)-(+)-对甲基苯亚磺酰胺 在 4 A molecular sieve 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 (S)-N-[[ethoxy(phenyl)phosphoryl]-phenylmethyl]-4-methylbenzenesulfinamide
  参考文献：
  名称：

  Interesting by-products in the synthesis of chiral α-aminophosphinates from enantiopure sulfinimines

  摘要：

  A new reaction of enantiopure sulfinimines and ethyl phenylphosphinate is given. Several unexpected products were isolated and identified, their mechanism of formation is proposed. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.151

文献信息

• Interesting by-products in the synthesis of chiral α-aminophosphinates from enantiopure sulfinimines
  作者：Andrea Szabó、Zsuzsa M Jászay、László Töke、Imre Petneházy

  DOI：10.1016/j.tetlet.2003.12.151

  日期：2004.2

  A new reaction of enantiopure sulfinimines and ethyl phenylphosphinate is given. Several unexpected products were isolated and identified, their mechanism of formation is proposed. (C) 2004 Elsevier Ltd. All rights reserved.