2-[4-(Tert-butyl)phenyl]-1-hydrazinecarbothioamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(Tert-butyl)phenyl]-1-hydrazinecarbothioamide
• 英文别名: (4-tert-butylanilino)thiourea
• 化学式: C₁₁H₁₇N₃S
• 分子量: 223.34
• InChiKey: ZYCPJGDYJAJKDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] TRKA AS A TARGET FOR INHIBITING APP CLEAVAGE AND/OR PROGRESSION OF ALZHEIMER'S DISEASE<br/>[FR] TRKA COMME CIBLE POUR L'INHIBITION DU CLIVAGE D'APP ET/OU LA PROGRESSION DE LA MALADIE D'ALZHEIMER
  申请人：BUCK INST FOR RES ON AGING

  公开号：WO2013026021A2

  公开（公告）日：2013-02-21

  In various embodiments method are provided for inhibiting (partially or fully) the C-terminal cleavage of APP resulting in the formation of APP-C31 peptide and APPneo (APP664) in a mammal. The methods typically involve administering or causing to be administered to the mammal a TrkA kinase inhibitor in an amount sufficient to reduce C-terminal cleavage of APP and production of a C31 peptide and/or APPneo. In certain embodiments the inhibitor comprises ADDN-1351 or a derivative thereof.