N-methyl-2-methylsulfanyl-6-(trifluoromethyl)pyrimidin-4-amine | 339019-60-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-methyl-2-methylsulfanyl-6-(trifluoromethyl)pyrimidin-4-amine
• CAS: 339019-60-2
• 化学式: C₇H₈F₃N₃S
• 分子量: 223.22
• InChiKey: HFXLWBUAPNCQQH-UHFFFAOYSA-N

物化性质

• 沸点：
  306.1±42.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] PYRROLYL SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7-ONES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS<br/>[FR] PYRIDO[2,3-D]PYRIMIDIN-7-ONES PYRROLYL-SUBSTITUEES ET DERIVES DE CES DERNIERES UTILISES COMME AGENTS THERAPEUTIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2005105801A1

  公开（公告）日：2005-11-10

  The present invention provides pyrimidines of Formula (I): wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I).

  本发明提供了式（I）的嘧啶类化合物：其中R2、R4、R5、R6、R8和J具有规范中定义的任何值，并其药学上可接受的盐，可用作治疗疾病的药物，包括炎症性疾病、心血管疾病和癌症。还提供了包含一种或多种式（I）化合物的药物组合物。
• Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents
  申请人：Bruendl Michelle Marie

  公开号：US20080255162A1

  公开（公告）日：2008-10-16

  The present invention provides pyrimidines of Formula I: wherein R 2 , R 4 , R 5 , R 6 , R 8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

  本发明提供了式I的嘧啶化合物：其中R2、R4、R5、R6、R8和J具有规范中定义的任何值，以及其药学上可接受的盐，可用作治疗疾病的药物，包括炎症性疾病、心血管疾病和癌症。还提供了包含一个或多个式I化合物的制药组合物。
• PYRROLYL SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7-ONES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1749004B1

  公开（公告）日：2007-09-19