Benzenesulfonamide, 4-ethoxy-3-(1-methylethyl)-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzenesulfonamide, 4-ethoxy-3-(1-methylethyl)-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-
• 英文别名: 4-ethoxy-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-3-propan-2-ylbenzenesulfonamide
• 化学式: C₂₂H₂₈N₂O₃S
• mdl: MFCD05859704
• 分子量: 400.5
• InChiKey: ZGPCCQUXHLDYJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• GANGLIOSIDE GD2 AS A MARKER AND TARGET ON CANCER STEM CELLS
  申请人：Board of Regents , The University of Texas System

  公开号：US20150044233A1

  公开（公告）日：2015-02-12

  Methods for determining the presence of cancer stem cells by detecting GD2 expression. Also provided are methods for reducing proliferation of cancer stem cells by contacting the cells with a GD2 targeting agent, such as an anti-GD2 antibody or a GD3 synthase inhibitor. GD3 synthase inhibitor compounds are also provided.
• US9846160B2
  申请人：——

  公开号：US9846160B2

  公开（公告）日：2017-12-19
• [EN] GANGLIOSIDE GD2 AS A MARKER AND TARGET ON CANCER STEM CELLS<br/>[FR] GANGLIOSIDE GD2 EN TANT QUE MARQUEUR ET CIBLE SUR DES CELLULES SOUCHES CANCÉREUSES
  申请人：UNIV TEXAS

  公开号：WO2013130603A1

  公开（公告）日：2013-09-06

  Methods for determining the presence of cancer stem cells by detecting GD2 expression. Also provided are methods for reducing proliferation of cancer stem cells by contacting the cells with a GD2 targeting agent, such as an anti-GD2 antibody or a GD3 synthase inhibitor. GD3 synthase inhibitor compounds are also provided.