6,7-dimethoxy-2-methylamino-4-(3'-phenyl-3-biphenylyl)quinazoline | 234751-82-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6,7-dimethoxy-2-methylamino-4-(3'-phenyl-3-biphenylyl)quinazoline
• 英文别名: 6,7-dimethoxy-N-methyl-4-[3-(3-phenylphenyl)phenyl]quinazolin-2-amine
• CAS: 234751-82-7
• 化学式: C₂₉H₂₅N₃O₂
• 分子量: 447.536
• InChiKey: PQRCQUXXPWVIRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  56.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(3-bromophenyl)-6,7-dimethoxy-2-methylaminoquinazoline 、 3-联苯硼酸 生成 6,7-dimethoxy-2-methylamino-4-(3'-phenyl-3-biphenylyl)quinazoline
  参考文献：
  名称：

  Nitrogenous heterocyclic derivatives and medicine thereof

  摘要：

  本发明提供了一种新型的含氮杂环化合物，该化合物作为磷酸二酯酶-4抑制剂是有用的，以及包含该化合物的药物。此外，本发明还提供了一种由下列公式表示的含氮杂环化合物，其盐或水合物，以及包含它们的药物。 其中，环A是可以含有杂原子的芳香烃环，环B代表（a）饱和烃环，（b）不饱和烃环，（c）饱和杂环或（d）不饱和杂环，所有这些都可能含有取代基团。

  公开号：

  US06352989B1

文献信息

• Nitrogen-containing heterocyclic compounds and medicaments containing the compounds
  申请人：Eisai Co., Ltd.

  公开号：US20020055516A1

  公开（公告）日：2002-05-09

  The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same. 1

  本发明提供了一种新型含氮杂环化合物，可用作磷酸二酯酶-4抑制剂，以及包含该化合物的药物。此外，本发明提供了一种由以下公式表示的含氮杂环化合物，其盐或水合物，以及包含该化合物的药物。 1
• NITROGENOUS HETEROCYCLIC DERIVATIVES AND MEDICINE THEREOF
  申请人：Eisai Co., Ltd.

  公开号：EP1052254A1

  公开（公告）日：2000-11-15

  The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same. Wherein the ring A is an aromatic hydrocarbon ring which may have a heteroatom, the ring B represents (a) a saturated hydrocarbon ring, (b) an unsaturated hydrocarbon ring, (c) a saturated heterocyclic ring or (d) an unsaturated heterocyclic ring, all of which may have a substituent group, R1 represents hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted with a halogen atom, a C1-6 alkoxy group which may be substituted with a halogen atom, etc., R2 and R3 are the same as or different from and represent hydrogen atom, a C1-6 alkyl group which may have a substituent group, a C3-7 cycloalkyl group which may have a substituent group, etc., R4, R5, R6 and R7 are the same as or different from each other and each represent hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted with a halogen atom, a C3-7 cycloalkyl group which may have a substituent group, a C1-6 alkoxy group which may have a substituent group, etc., neighboring R3, R4, R5 and R6 may be combined to form a ring which may be substituted with a C1-6 alkyl group which may contain a heteroatom, L represents a single bond, (a) a C1-6 alkylene group, (b) a C2-6 alkenylene group, (c) a C2-6 alkynylene group, all of which may have a substituent group, or a group represented by the formula -E-G- (wherein E represents oxygen atom, sulfur atom, the formula -CO-, -SO-, -SO2-, -N(R8)- (R8 is hydrogen atom, a C1-6 alkyl group or an acyl group), -N(R9)-CO- (R9 is hydrogen atom or a C1-6 alkyl group), or -(CH2)m- which may have a substituent group (m is an integer of 0 to 6), and G represents a sulfonyl group, the formula -N(R10)- (R10 represents hydrogen atom, a C1-6 alkyl group or an acyl group) or -(CH2)n- (n is an integer of 0 to 6)), and X and Y are the same as or different from each other and each represents nitrogen atom, =CH- or a carbon atom which may be substituted with a C1-6 alkyl group which may have a substituent group, provided that X and Y are not simultaneously carbon atoms which may be substituted with a C1-3 alkyl group.

  本发明提供了一种可用作磷酸二酯酶-4 抑制剂的新型含氮杂环化合物，以及包含该化合物的药物。此外，本发明还提供了由下式表示的含氮杂环化合物、其盐或水合物，以及由其组成的药物。 其中，环 A 是芳香烃环，可带有一个杂原子，环 B 代表(a) 饱和烃环、(b) 不饱和烃环、(c) 饱和杂环或(d) 不饱和杂环，均可带有取代基，R1 代表氢原子、卤素原子、可被卤素原子取代的 C1-6 烷基、可被卤素原子取代的 C1-6 烷氧基等、R2和R3相同或不同，分别代表氢原子、可被取代基取代的C1-6烷基、可被取代基取代的C3-7环烷基等，R4、R5、R6和R7相同或不同，分别代表氢原子、卤素原子、可被卤素原子取代的C1-6烷基、可被取代基取代的C3-7环烷基、可被取代基取代的C1-6烷氧基等、相邻的 R3、R4、R5 和 R6 可结合形成一个环，该环可被一个可能含有杂原子的 C1-6 烷基取代，L 代表单键、(a) C1-6 亚烷基、(b) C2-6 亚烯基、(c) C2-6 亚炔基、所有这些基团均可带有取代基，或由式-E-G-代表的基团（其中 E 代表氧原子、硫原子、式-CO-、-SO-、-SO2-、-N(R8)-（R8 为氢原子、C1-6 烷基或酰基）、-N(R9)-CO-（R9 为氢原子或 C1-6 烷基）、或-(CH2)m-，其中可带有取代基（m 为 0-6 的整数），G 代表磺酰基，式中 -N(R10)- （R10 代表氢原子、C1-6 烷基或酰基）或-(CH2)n-（n 为 0-6 的整数）、X和Y彼此相同或不同，各自代表氮原子、＝CH-或可被C1-6烷基取代的碳原子，该碳原子可带有取代基，但X和Y不能同时是可被C1-3烷基取代的碳原子。
• US6352989B1
  申请人：——

  公开号：US6352989B1

  公开（公告）日：2002-03-05
• US6800644B2
  申请人：——

  公开号：US6800644B2

  公开（公告）日：2004-10-05
• Nitrogenous heterocyclic derivatives and medicine thereof
  申请人：Eisai Co., Ltd.

  公开号：US06352989B1

  公开（公告）日：2002-03-05

  The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same. wherein the ring A is an aromatic hydrocarbon ring which may have a heteroatom, the ring B represents (a) a saturated hydrocarbon ring, (b) an unsaturated hydrocarbon ring, (c) a saturated heterocyclic ring or (d) an unsaturated heterocyclic ring, all of which may have a substituent group.

  本发明提供了一种新型的含氮杂环化合物，该化合物作为磷酸二酯酶-4抑制剂是有用的，以及包含该化合物的药物。此外，本发明还提供了一种由下列公式表示的含氮杂环化合物，其盐或水合物，以及包含它们的药物。 其中，环A是可以含有杂原子的芳香烃环，环B代表（a）饱和烃环，（b）不饱和烃环，（c）饱和杂环或（d）不饱和杂环，所有这些都可能含有取代基团。