(2R)-2-azaniumyl-2-(4-phenylphenyl)acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-azaniumyl-2-(4-phenylphenyl)acetate
• 化学式: C14H13NO2
• mdl: MFCD02662412
• 分子量: 227.26
• InChiKey: BMWOGALGPJNHSP-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Stabilized GLP-1 Analogs
  申请人：Bachovchin William W.

  公开号：US20090306338A1

  公开（公告）日：2009-12-10

  Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have GLP-1-like activity of longer duration than native GLP-1 and/or the GLP-1 receptor has a greater affinity for the analogs than native GLP-1. Other polypeptide analogs of the invention include a) a base amino acid sequence at least 50% identical to a GLP-1 fragment in which the amino acid residue in the base amino acid sequence corresponding to the P′ 1 residue of GLP-1 is an amino acid analog having a tetrasubstituted C β carbon; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have the properties indicated above. The invention also includes methods of treatment where these analogs are administered.
• US8318668B2
  申请人：——

  公开号：US8318668B2

  公开（公告）日：2012-11-27
• [EN] STABILIZED GLP-1 ANALOGS<br/>[FR] ANALOGUES DE GLP-1 STABILISES
  申请人：TUFTS COLLEGE

  公开号：WO2007030519A2

  公开（公告）日：2007-03-15

  [EN] Polypeptide analogs of the invention that include a) a base amino acid sequence at least 80% identical to one of a GLP-1 fragment; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have GLP-1 -like activity of longer duration than native GLP-1 and/or the GLP-1 receptor has a greater affinity for the analogs than native GLP-1 . Other polypeptide analogs of the invention include a) a base amino acid sequence at least 50% identical to a GLP-1fragment in which the amino acid residue in the base amino acid sequence corresponding to the P'₁ residue of GLP-1 is an amino acid analog having a tetrasubstituted C_ß carbon; and b) amino acid residues attached to the carboxy terminus of the base amino acid sequence, where the analogs have the properties indicated above. The invention also includes methods of treatment where these analogs are administered.
  [FR] La présente invention se rapporte à des analogues polypeptidiques, qui contiennent: (a) une séquence d'acides aminés de base identique à au moins 80 % à un fragment GLP-1 ; et (b) des résidus d'acides aminés liés à l'extrémité carboxy de la séquence d'acides aminés de base. Lesdits analogues présentent une activité de type GLP-1 de plus longue durée que GLP-1 natif, et/ou le récepteur GLP-1 possède une plus grande affinité pour les analogues que pour GLP-1 natif. D'autres analogues polypeptidiques selon l'invention, qui possèdent également les propriétés susmentionnées, contiennent : (a) une séquence d'acides aminés de base identique à au moins 50 % à un fragment GLP-1, le résidu d'acide aminé contenu dans la séquence d'acides aminés qui correspond au résidu P'₁ de GLP-1 étant un analogue d'acide aminé renfermant un carbone C_ß tétrasubstitué ; et (b) des résidus d'acides aminés liés à l'extrémité carboxy de la séquence d'acides aminés de base. L'invention a également trait à des méthodes de traitement consistant à administrer lesdits analogues.
• [EN] ANTIMICROBIAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIMICROBIENS
  申请人：UNIV MONASH

  公开号：WO2012051663A1

  公开（公告）日：2012-04-26

  The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.