(3-Methyl-4-phenoxy-phenyl)-(6-piperidin-4-ylethynyl-pyrido[3,4-d]pyrimidin-4-yl)-amine | 287192-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Methyl-4-phenoxy-phenyl)-(6-piperidin-4-ylethynyl-pyrido[3,4-d]pyrimidin-4-yl)-amine
• 英文别名: N-(3-methyl-4-phenoxyphenyl)-6-(2-piperidin-4-ylethynyl)pyrido[3,4-d]pyrimidin-4-amine
• CAS: 287192-44-3
• 化学式: C₂₇H₂₅N₅O
• 分子量: 435.528
• InChiKey: IHGOIEFDJGYXTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  72
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  EtOAc-hexanes 、 (6-chloro-pyrido[3,4-d]pyrimidin-4-yl)-(3-methyl-4-phenoxy-phenyl)-amine hydrochloride 、 1,4-双(二苯基膦)丁烷 、 1-Boc-4-乙炔基哌啶 生成 (3-Methyl-4-phenoxy-phenyl)-(6-piperidin-4-ylethynyl-pyrido[3,4-d]pyrimidin-4-yl)-amine
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Substituted bicyclic derivatives useful as anticancer agents
  申请人：——

  公开号：US20010034351A1

  公开（公告）日：2001-10-25

  The invention relates to compounds of the formula 1 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R 1 , R 3 and R 4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

  本发明涉及公式11的化合物及其药学上可接受的盐和溶剂化物，其中A、X、R1、R3和R4的定义如本文所述。本发明还涉及使用公式1的化合物治疗哺乳动物中的异常细胞生长的方法，并涉及含有公式1的化合物的治疗此类疾病的制药组合物。本发明还涉及制备公式1的化合物的方法。
• SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS
  申请人：Pfizer Products Inc.

  公开号：EP1147093B1

  公开（公告）日：2007-04-11
• US6284764B1
  申请人：——

  公开号：US6284764B1

  公开（公告）日：2001-09-04
• US6541481B2
  申请人：——

  公开号：US6541481B2

  公开（公告）日：2003-04-01
• [EN] SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS<br/>[FR] DERIVES BICYCLIQUES SUBSTITUES UTILES EN TANT QU'AGENTS ANTICANCEREUX
  申请人：PFIZER PROD INC

  公开号：WO2000044728A1

  公开（公告）日：2000-08-03

  The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R?1, R3 and R4¿ are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).