ethyl 2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-thio>-acetate | 140367-00-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: ethyl 2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-thio>-acetate
• 英文别名: Ethyl 2-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)sulfanyl]acetate
• CAS: 140367-00-6
• 化学式: C₁₅H₂₀O₃S
• 分子量: 280.388
• InChiKey: HYOBOWJUPFJBIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-thio>-acetate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 生成 2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-thio>-N-n-propyl-ethylamine
  参考文献：
  名称：

  Synthesis and dopamine receptor affinities of 1-aminoethylhetero-tetralines

  摘要：

  A series of 1-aminoethylhetero-tetralines 3-6, which can be considered as opened-structure analogues of previously studied dopaminergic compounds 2, were synthesized. In the binding studies, to evaluate D-1 and D-2 activity, no significant affinity was observed towards both dopaminergic receptors.

  DOI：

  10.1016/0223-5234(91)90129-b
• 作为产物：
  描述：

  阿戈美拉汀杂质醇(A) 在 氯化亚砜 、 三乙胺 作用下， 反应 3.0h， 生成 ethyl 2-<(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-thio>-acetate
  参考文献：
  名称：

  Synthesis and dopamine receptor affinities of 1-aminoethylhetero-tetralines

  摘要：

  A series of 1-aminoethylhetero-tetralines 3-6, which can be considered as opened-structure analogues of previously studied dopaminergic compounds 2, were synthesized. In the binding studies, to evaluate D-1 and D-2 activity, no significant affinity was observed towards both dopaminergic receptors.

  DOI：

  10.1016/0223-5234(91)90129-b

文献信息

• High Affinity and Selectivity on 5-HT1A Receptor of 1-Aryl-4-[(1-tetralin)alkyl]piperazines. 2
  作者：Roberto Perrone、Francesco Berardi、Nicola A. Colabufo、Marcello Leopoldo、Vincenzo Tortorella、Francesco Fiorentini、Vincenzo Olgiati、Alberto Ghiglieri、Stefano Govoni

  DOI：10.1021/jm00006a013

  日期：1995.3

  in order to increase the selectivity on the 5-HT1A versus D-2, alpha 1, sigma, and other 5-HT receptors. Many changes have been effected on previous structures of type 3(1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines). Several synthetic procedures were followed to obtain the final products, depending on the presence or absence of a double bond, as well as of a heteroatom on the side chain

  为了增加5-HT1A对D-2，α1，σ和其他5-HT受体的选择性，合成了几种在侧链末端具有四氢萘部分的4-烷基-1-芳基哌嗪。许多变化已影响先前的类型3（1-芳基-4- [3-（1,2-二氢萘-4-基）-正丙基]哌嗪的结构。遵循几种合成程序以获得最终产物，这取决于双键以及侧链上杂原子的存在与否。在第一种情况下，可以广泛使用格利雅（Grignard）反应，而在第二种情况下，可以采用常规的合成方法。通过放射受体结合试验评估最终化合物对多巴胺D-1和D-2、5-羟色胺5-HT1A，5-HT1B，5-HT1C和5-HT2，α1肾上腺素和sigma受体的体外活性。
• N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY
  申请人：FARMITALIA CARLO ERBA S.r.l.

  公开号：EP0647222A1

  公开（公告）日：1995-04-12
• [EN] N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY<br/>[FR] N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE A ACTIVITE SEROTONINERGIQUE, DOPAMINERGIQUE ET ADRENERGIQUE
  申请人：FARMITALIA CARLO ERBA S.R.L.

  公开号：WO1994000441A1

  公开（公告）日：1994-01-06

  (EN) N(hetero)-aryl-N(hetero)-tetralinalkyl piperazine having serotoninergic, dopaminergic and adrenergic activity, the processes for their preparation and relative therapeutic compositions for the treatment of anxiety generated by depression, for the treatment of schizophrenia, cerebral ischemia, opium like and psycho stimulant substances abuse syndromes consciousness disorders such as senile dementia, vigilance and memory disorders. Parkinson's and Alzheimer's diseases and for the treatment of arterial hypertension.(FR) N(hétéro)-aryl-N(hétéro)-tétralin-alkyl-pipérazine à activité serotoninergique, dopaminergique et adrénergique, ses procédés de préparation, et compositions thérapeutiques associées destinées au traitement de l'angoisse provoquée par la dépression, au traitement de la schizophrénie, des accès ischémiques cérébraux, des syndromes dus à l'usage de substances psychostimulantes et opiacées, des troubles de la conscience tels que la démence sénile et les troubles de la vigilance et de la mémoire, et des maladies de Parkinson et d'Alzheimer, ainsi qu'au traitement de l'hypertension artérielle.
• Synthesis and dopamine receptor affinities of 1-aminoethylhetero-tetralines
  作者：R Perrone、F Berardi、V Tortorella、S Govoni、MD Lograno、E Daniele

  DOI：10.1016/0223-5234(91)90129-b

  日期：1991.12

  A series of 1-aminoethylhetero-tetralines 3-6, which can be considered as opened-structure analogues of previously studied dopaminergic compounds 2, were synthesized. In the binding studies, to evaluate D-1 and D-2 activity, no significant affinity was observed towards both dopaminergic receptors.